Epigenetics & Nuclear Signaling Antibodies 3

Anti-SETD1A Antibody (CAB17314)

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SKU:
CAB17314
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SETD1A Antibody
Antibody SKU:CAB17314
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SETD1A
Application:IF
Recommended Dilution:IF 1:20 - 1:200
Reactivity:Human, Rat
Positive Samples:
Immunogen:Recombinant protein of human SETD1A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9739
Uniprot:O15047
Cellular Location:
Calculated MW:186kDa
Observed MW:Refer to figures
Synonyms:Set1, KMT2F, Set1A, SETD1A, SET1A
Background:The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily.
UniProt Protein Function:SETD1A: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: histone methyltransferase complex; nuclear chromatin; nuclear speck; nucleoplasm; nucleus

Molecular Function:beta-catenin binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription factor binding

NCBI Summary:The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]
UniProt Code:O15047
NCBI GenInfo Identifier:749385041
NCBI Gene ID:9739
NCBI Accession:NM_014712.2
UniProt Secondary Accession:O15047,Q6PIF3, Q8TAJ6, A6NP62,
UniProt Related Accession:O15047
Molecular Weight:~61 kDa
NCBI Full Name:Homo sapiens SET domain containing 1A (SETD1A), mRNA
NCBI Synonym Full Names:SET domain containing 1A
NCBI Official Symbol:SETD1A  
NCBI Official Synonym Symbols:Set1; KMT2F; Set1A  
NCBI Protein Information:histone-lysine N-methyltransferase SETD1A
UniProt Protein Name:Histone-lysine N-methyltransferase SETD1A
UniProt Synonym Protein Names:Lysine N-methyltransferase 2F; SET domain-containing protein 1A; hSET1A; Set1/Ash2 histone methyltransferase complex subunit SET1
UniProt Gene Name:SETD1A  
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