Cell Biology Antibodies 11

Anti-SETBP1 Antibody (CAB7212)

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SKU:
CAB7212
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SETBP1 Antibody
Antibody SKU:CAB7212
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human SETBP1 (NP_001123582.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Rat
Positive Samples:NCI-H460, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human SETBP1 (NP_001123582.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MESR ETLS SSRQ RGGE SDFL PVSS AKPP AAPG CAGE PLLS TPGP GKGI PVGG ERME PEEE DELG SGRD VDSN SNAD SEKW VAGD GLEE QEFS IKEA NFTE GSLK LKIQ TTKR AKKP PKNL ENYI CPPE IKIT IKQS GDQK VSRA GKNS KATK EEER SHSK KKLL TASD LAAS DLKG FQPQ IKDS SKEE VWKR RGGQ GIPF KKQF LSQE RAMC FSCP RNPF PAKP GSLT LPFH SEPA VWAQ EV
Gene ID:26040
Uniprot:Q9Y6X0
Cellular Location:Nucleus
Calculated MW:26kDa/175kDa
Observed MW:175kDa
Synonyms:SETBP1, MRD29, SEB
Background:This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SETBP1: Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nucleus

Molecular Function:DNA binding

Disease: Mental Retardation, Autosomal Dominant 29; Schinzel-giedion Midface Retraction Syndrome

NCBI Summary:This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:Q9Y6X0
NCBI GenInfo Identifier:294862494
NCBI Gene ID:26040
NCBI Accession:Q9Y6X0.3
UniProt Secondary Accession:Q9Y6X0,Q6P6C3, Q9UEF3, A6H8W5,
UniProt Related Accession:Q9Y6X0
Molecular Weight:Calculated MW: 26kDa/175kDaObserved MW: 175kDa
NCBI Full Name:SET-binding protein
NCBI Synonym Full Names:SET binding protein 1
NCBI Official Symbol:SETBP1  
NCBI Official Synonym Symbols:SEB; MRD29  
NCBI Protein Information:SET-binding protein
UniProt Protein Name:SET-binding protein
Protein Family:SET-binding protein
UniProt Gene Name:SETBP1  
UniProt Entry Name:SETBP_HUMAN
Anti-SETBP1 Antibody (CAB7212)Western blot analysis of extracts of various cell lines, using SETBP1 antibody (CAB7212) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-SETBP1 Antibody (CAB7212)Immunofluorescence analysis of A-549 cells using SETBP1 antibody (CAB7212).
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