Cell Biology Antibodies 9
Anti-SESN3 Antibody (CAB5164)
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- SKU:
- CAB5164
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SESN3 Antibody |
| Antibody SKU: | CAB5164 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNRG GGSP SAAA NYLL CTNC RKVL RKDK RIRV SQPL TRGP SAFI PEKE VVQA NTVD ERTN FLVE EYST SGRL DNIT QVMS LHTQ YLES FLRS QFYM LRMD GPLP LPYR HYIA IMAA ARHQ CSYL INMH VDEF LKTG GIAE WLNG LEYV PQRL KNLN EINK LLAH RPWL ITKE HIQK LVKT GENN WSLP ELVH AVVL LAHY HALA SFVF GSGI NPER DPEI SNGF RLIS VNNF CVCD LAND NNIE NASL SGSN FGIV DSLS ELEA LMER MKRL QEER EDEE ASQE EMST RFEK EKKE SLFV VSGD TFHS FP |
| Gene ID: | 143686 |
| Uniprot: | P58005 |
| Cellular Location: | |
| Calculated MW: | 36kDa/41kDa/57kDa |
| Observed MW: | 50kDa |
| Synonyms: | SESN3, SEST3, sestrin-3 |
| Background: | This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SESN3: a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q21 Cellular Component: nucleus Biological Process: regulation of protein kinase B signaling cascade; glucose homeostasis; response to insulin stimulus |
| NCBI Summary: | This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
| UniProt Code: | P58005 |
| NCBI GenInfo Identifier: | 20141774 |
| NCBI Gene ID: | 143686 |
| NCBI Accession: | P58005.2 |
| UniProt Secondary Accession: | P58005,Q96AD1, B7Z7P9, |
| UniProt Related Accession: | P58005 |
| Molecular Weight: | 492 |
| NCBI Full Name: | Sestrin-3 |
| NCBI Synonym Full Names: | sestrin 3 |
| NCBI Official Symbol: | SESN3 |
| NCBI Official Synonym Symbols: | SEST3 |
| NCBI Protein Information: | sestrin-3 |
| UniProt Protein Name: | Sestrin-3 |
| Protein Family: | Sestrin |
| UniProt Gene Name: | SESN3 |
| UniProt Entry Name: | SESN3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SESN3 antibody (CAB5164) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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