Cell Biology Antibodies 11
Anti-SESN2 Antibody (CAB7515)
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- SKU:
- CAB7515
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SESN2 Antibody |
| Antibody SKU: | CAB7515 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 211-480 of human SESN2 (NP_113647.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Jurkat, Mouse kidney, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 211-480 of human SESN2 (NP_113647.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VFGC GILP EGDA DGSP APQA PTPP SEQS SPPS RDPL NNSG GFES ARDV EALM ERMQ QLQE SLLR DEGT SQEE MESR FELE KSES LLVT PSAD ILEP SPHP DMLC FVED PTFG YEDF TRRG AQAP PTFR AQDY TWED HGYS LIQR LYPE GGQL LDEK FQAA YSLT YNTI AMHS GVDT SVLR RAIW NYIH CVFG IRYD DYDY GEVN QLLE RNLK VYIK TVAC YPEK TTRR MYNL FWRH FRHS EKVH VNLL LLEA RMQA ALLY ALRA ITRY MT |
| Gene ID: | 83667 |
| Uniprot: | P58004 |
| Cellular Location: | |
| Calculated MW: | 54kDa |
| Observed MW: | 57kDa |
| Synonyms: | SESN2, HI95, SES2, SEST2, sestrin-2 |
| Background: | This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. |
| UniProt Protein Function: | SESN2: Involved in the reduction of peroxiredoxins. Widely expressed. Belongs to the sestrin family. |
| UniProt Protein Details: | Protein type:Enzyme, misc. Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: cytoplasm; cytosol Molecular Function:oxidoreductase activity, acting on peroxide as acceptor; protein binding; sulfiredoxin activity Biological Process: DNA damage response, signal transduction by p53 class mediator |
| NCBI Summary: | This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P58004 |
| NCBI GenInfo Identifier: | 13633882 |
| NCBI Gene ID: | 83667 |
| NCBI Accession: | P58004.1 |
| UniProt Secondary Accession: | P58004,Q5T7D0, Q96SI5, |
| UniProt Related Accession: | P58004 |
| Molecular Weight: | 54,494 Da |
| NCBI Full Name: | Sestrin-2 |
| NCBI Synonym Full Names: | sestrin 2 |
| NCBI Official Symbol: | SESN2 |
| NCBI Official Synonym Symbols: | HI95; SES2; SEST2 |
| NCBI Protein Information: | sestrin-2 |
| UniProt Protein Name: | Sestrin-2 |
| UniProt Synonym Protein Names: | Hypoxia-induced gene |
| Protein Family: | Sestrin |
| UniProt Gene Name: | SESN2 |
| UniProt Entry Name: | SESN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SESN2 antibody (CAB7515) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human gastric using SESN2 antibody (CAB7515) at dilution of 1:100 (40x lens). |
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