Cell Biology Antibodies 14
Anti-SERPINF1 Antibody (CAB16946)
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- SKU:
- CAB16946
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SERPINF1 Antibody |
| Antibody SKU: | CAB16946 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human SERPINF1. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Human serum, HepG2, A375, U2OS |
| Immunogen: | A synthetic peptide of human SERPINF1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5176 |
| Uniprot: | P36955 |
| Cellular Location: | Melanosome, Secreted |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
 | Western blot - SERPINF1 Rabbit pAb (CAB16946) |
| Synonyms: | SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35 |
| Background: | This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. |
| UniProt Protein Function: | PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; extracellular region; melanosome; basement membrane Molecular Function:serine-type endopeptidase inhibitor activity Biological Process: cell proliferation; positive regulation of neurogenesis; negative regulation of angiogenesis; ovulation cycle; retina development in camera-type eye; short-term memory; response to arsenic; multicellular organismal development; negative regulation of inflammatory response; response to acidity; kidney development; aging Disease: Osteogenesis Imperfecta, Type Vi |
| NCBI Summary: | The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P36955 |
| NCBI GenInfo Identifier: | 313104314 |
| NCBI Gene ID: | 5176 |
| NCBI Accession: | P36955.4 |
| UniProt Secondary Accession: | P36955,Q13236, Q2TU83, Q96CT1, Q96R01, Q9BWA4, F1T092 |
| UniProt Related Accession: | P36955 |
| Molecular Weight: | 46,312 Da |
| NCBI Full Name: | Pigment epithelium-derived factor |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| NCBI Official Symbol: | SERPINF1 |
| NCBI Official Synonym Symbols: | OI6; OI12; PEDF; EPC-1; PIG35 |
| NCBI Protein Information: | pigment epithelium-derived factor; serpin F1; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| UniProt Protein Name: | Pigment epithelium-derived factor |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1 |
| UniProt Gene Name: | SERPINF1 |
| UniProt Entry Name: | PEDF_HUMAN |
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