Name: Anti-SERPINE2 Antibody (CAB5329)
Brand: Developmental Biology
SKU: CAB5329
Availability: OutOfStock

Antibody Name:	Anti-SERPINE2 Antibody
Antibody SKU:	CAB5329
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-398 of human SERPINE2 (NP_006207.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Mouse
Positive Samples:	Mouse brain, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-398 of human SERPINE2 (NP_006207.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	SHFN PLSL EELG SNTG IQVF NQIV KSRP HDNI VISP HGIA SVLG MLQL GADG RTKK QLAM VMRY GVNG VGKI LKKI NKAI VSKK NKDI VTVA NAVF VKNA SEIE VPFV TRNK DVFQ CEVR NVNF EDPA SACD SINA WVKN ETRD MIDN LLSP DLID GVLT RLVL VNAV YFKG LWKS RFQP ENTK KRTF VAAD GKSY QVPM LAQL SVFR CGST SAPN DLWY NFIE LPYH GESI SMLI ALPT ESST PLSA IIPH ISTK TIDS WMSI MVPK RVQV ILPK FTAV AQTD LKEP LKVL GITD MFDS SKAN FAKI TTGS ENLH VSHI LQKA KIEV SEDG TKAS AATT AILI ARSS PPWF IVDR PFLF FIRH NPTG AVLF MGQI NKP
Gene ID:	5270
Uniprot:	P07093
Cellular Location:	Secreted, extracellular space
Calculated MW:	44kDa/45kDa
Observed MW:	44kDa

Synonyms:	SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
Background:	This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q36.1 Cellular Component: cell soma; cytosol; extracellular matrix; extracellular region; extracellular space; extrinsic to external side of plasma membrane; neuromuscular junction Molecular Function:glycosaminoglycan binding; heparin binding; protein binding; receptor binding; serine-type endopeptidase inhibitor activity Biological Process: blood coagulation; cerebellar granular layer morphogenesis; detection of mechanical stimulus involved in sensory perception; embryo implantation; mating plug formation; negative regulation of blood coagulation; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of proteolysis; negative regulation of smoothened signaling pathway; positive regulation of astrocyte differentiation; regulation of cell migration; regulation of synaptic transmission, glutamatergic; regulation of timing of cell differentiation; response to radiation; secretory granule organization and biogenesis
NCBI Summary:	This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:	P07093
NCBI GenInfo Identifier:	121110
NCBI Gene ID:	5270
NCBI Accession:	P07093.1
UniProt Related Accession:	P07093
Molecular Weight:
NCBI Full Name:	Glia-derived nexin
NCBI Synonym Full Names:	serpin family E member 2
NCBI Official Symbol:	SERPINE2
NCBI Official Synonym Symbols:	GDN; PI7; PN1; PNI; PI-7; PN-1; GDNPF
NCBI Protein Information:	glia-derived nexin
UniProt Protein Name:	Glia-derived nexin
UniProt Synonym Protein Names:	Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2
UniProt Gene Name:	SERPINE2
UniProt Entry Name:	GDN_HUMAN

	Western blot analysis of extracts of various cell lines, using SERPINE2 antibody (CAB5329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
	Immunohistochemistry of paraffin-embedded mouse kidney using SERPINE2 Antibody (CAB5329) at dilution of 1:100 (40x lens).