Developmental Biology
Anti-SERPINE2 Antibody (CAB14540)
- SKU:
- CAB14540
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SERPINE2 Antibody |
| Antibody SKU: | CAB14540 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-398 of human SERPINE2 (NP_006207.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-398 of human SERPINE2 (NP_006207.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LEEL GSNT GIQV FNQI VKSR PHDN IVIS PHGI ASVL GMLQ LGAD GRTK KQLA MVMR YGVN GVGK ILKK INKA IVSK KNKD IVTV ANAV FVKN ASEI EVPF VTRN KDVF QCEV RNVN FEDP ASAC DSIN AWVK NETR DMID NLLS PDLI DGVL TRLV LVNA VYFK GLWK SRFQ PENT KKRT FVAA DGKS YQVP MLAQ LSVF RCGS TSAP NDLW YNFI ELPY HGES ISML IALP TESS TPLS AIIP HIST KTID SWMS IMVP KRVQ VILP KFTA VAQT DLKE PLKV LGIT DMFD SSKA NFAK ITTG SENL HVSH ILQK AKIE VSED GTKA SAAT TAIL IARS SPPW FIVD RPFL FFIR HNPT GAVL FMGQ INKP |
| Gene ID: | 5270 |
| Uniprot: | P07093 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 44kDa/45kDa |
| Observed MW: | 44kDa |
| Synonyms: | SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI |
| Background: | This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q36.1 Cellular Component: cell soma; cytosol; extracellular matrix; extracellular region; extracellular space; extrinsic to external side of plasma membrane; neuromuscular junction Molecular Function:glycosaminoglycan binding; heparin binding; protein binding; receptor binding; serine-type endopeptidase inhibitor activity Biological Process: blood coagulation; cerebellar granular layer morphogenesis; detection of mechanical stimulus involved in sensory perception; embryo implantation; mating plug formation; negative regulation of blood coagulation; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of proteolysis; negative regulation of smoothened signaling pathway; positive regulation of astrocyte differentiation; regulation of cell migration; regulation of synaptic transmission, glutamatergic; regulation of timing of cell differentiation; response to radiation; secretory granule organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | P07093 |
| NCBI GenInfo Identifier: | 121110 |
| NCBI Gene ID: | 5270 |
| NCBI Accession: | P07093.1 |
| UniProt Related Accession: | P07093 |
| Molecular Weight: | |
| NCBI Full Name: | Glia-derived nexin |
| NCBI Synonym Full Names: | serpin family E member 2 |
| NCBI Official Symbol: | SERPINE2 |
| NCBI Official Synonym Symbols: | GDN; PI7; PN1; PNI; PI-7; PN-1; GDNPF |
| NCBI Protein Information: | glia-derived nexin |
| UniProt Protein Name: | Glia-derived nexin |
| UniProt Synonym Protein Names: | Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2 |
| UniProt Gene Name: | SERPINE2 |
| UniProt Entry Name: | GDN_HUMAN |
 | Western blot analysis of extracts of mouse testis, using SERPINE2 antibody (CAB14540) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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