Cardiovascular Antibodies
Anti-SERPIND1 Antibody (CAB5848)
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- SKU:
- CAB5848
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-SERPIND1 Antibody |
| Antibody SKU: | CAB5848 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-290 of human SERPIND1 (NP_000176.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, A-431, HepG2, 293T, Mouse liver, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-290 of human SERPIND1 (NP_000176.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GSKG PLDQ LEKG GETA QSAD PQWE QLNN KNLS MPLL PADF HKEN TVTN DWIP EGEE DDDY LDLE KIFS EDDD YIDI VDSL SVSP TDSD VSAG NILQ LFHG KSRI QRLN ILNA KFAF NLYR VLKD QVNT FDNI FIAP VGIS TAMG MISL GLKG ETHE QVHS ILHF KDFV NASS KYEI TTIH NLFR KLTH RLFR RNFG YTLR SVND LYIQ KQFP ILLD FKTK VREY YFAE AQIA DFSD PAFI SKTN NHIM KLTK GLIK DALE NIDP ATQM MIL |
| Gene ID: | 3053 |
| Uniprot: | P05546 |
| Cellular Location: | |
| Calculated MW: | 57kDa |
| Observed MW: | 57-69kDa |
| Synonyms: | SERPIND1, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10 |
| Background: | This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. |
| UniProt Protein Function: | SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: chemotaxis; blood coagulation Disease: Heparin Cofactor Ii Deficiency |
| NCBI Summary: | The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05546 |
| NCBI GenInfo Identifier: | 123055 |
| NCBI Gene ID: | 3053 |
| NCBI Accession: | P05546.3 |
| UniProt Secondary Accession: | P05546,Q6IBZ5, B2RAI1, D3DX34, |
| UniProt Related Accession: | P05546 |
| Molecular Weight: | 499 |
| NCBI Full Name: | Heparin cofactor 2 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
| NCBI Official Symbol: | SERPIND1 |
| NCBI Official Synonym Symbols: | HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673 |
| NCBI Protein Information: | heparin cofactor 2; serpin D1; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 |
| UniProt Protein Name: | Heparin cofactor 2 |
| UniProt Synonym Protein Names: | Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1 |
| Protein Family: | Heparin cofactor |
| UniProt Gene Name: | SERPIND1 |
| UniProt Entry Name: | HEP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPIND1 antibody (CAB5848) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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