Cardiovascular Antibodies
Anti-SERPINC1 Antibody (CAB11249)
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- SKU:
- CAB11249
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-SERPINC1 Antibody |
| Antibody SKU: | CAB11249 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SERPINC1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, K-562, Rat liver, Mouse plasma, Rat plasma, Human plasma |
| Immunogen: | A synthesized peptide derived from human SERPINC1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 462 |
| Uniprot: | P01008 |
| Cellular Location: | |
| Calculated MW: | 53kDa |
| Observed MW: | 58KDa |
 | Western blot - SERPINC1 Rabbit mAb (CAB11249) |
| Synonyms: | AT3, AT3D, ATIII, THPH7 |
| Background: | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| UniProt Protein Function: | SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 1q25.1 Cellular Component: extracellular space; plasma membrane; extracellular region Molecular Function:heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient Disease: Antithrombin Iii Deficiency |
| NCBI Summary: | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| UniProt Code: | P01008 |
| NCBI GenInfo Identifier: | 113936 |
| NCBI Gene ID: | 462 |
| NCBI Accession: | P01008.1 |
| UniProt Secondary Accession: | P01008,P78439, P78447, Q13815, Q5TC78, Q7KZ43, Q7KZ97 Q9UC78, B2R6P0, |
| UniProt Related Accession: | P01008 |
| Molecular Weight: | 464 |
| NCBI Full Name: | Antithrombin-III |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| NCBI Official Symbol: | SERPINC1 |
| NCBI Official Synonym Symbols: | AT3; AT3D; ATIII; THPH7 |
| NCBI Protein Information: | antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 |
| UniProt Protein Name: | Antithrombin-III |
| UniProt Synonym Protein Names: | Serpin C1 |
| UniProt Gene Name: | SERPINC1 |
| UniProt Entry Name: | ANT3_HUMAN |
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