Cell Biology Antibodies 2

Anti-SERPINB5 Antibody (CAB1179)

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SKU:
CAB1179
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SERPINB5 Antibody
Antibody SKU:CAB1179
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-189 of human SERPINB5 (NP_002630.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NCI-H460, HT-29, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-189 of human SERPINB5 (NP_002630.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EKEP LGNV LFSP ICLS TSLS LAQV GAKG DTAN EIGQ VLHF ENVK DVPF GFQT VTSD VNKL SSFY SLKL IKRL YVDK SLNL STEF ISST KRPY AKEL ETVD FKDK LEET KGQI NNSI KDLT DGHF ENIL ADNS VNDQ TKIL VVNA AYFV GKWM KKFS ESET KECP FRVN K
Gene ID:5268
Uniprot:P36952
Cellular Location:Secreted, extracellular space
Calculated MW:25kDa/42kDa
Observed MW:42kDa
Synonyms:SERPINB5, PI5, maspin, serpin B5
Background:
UniProt Protein Function:maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 18q21.33

Cellular Component: extracellular space; cytoplasm

Molecular Function:serine-type endopeptidase inhibitor activity; protein binding

Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation

UniProt Code:P36952
NCBI GenInfo Identifier:229462757
NCBI Gene ID:5268
NCBI Accession:P36952.2
UniProt Secondary Accession:P36952,Q6N0B4, Q8WW89, B2R6Y4,
UniProt Related Accession:P36952
Molecular Weight:25,763 Da
NCBI Full Name:Serpin B5
NCBI Synonym Full Names:serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Official Symbol:SERPINB5  
NCBI Official Synonym Symbols:PI5; maspin  
NCBI Protein Information:serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
UniProt Protein Name:Serpin B5
UniProt Synonym Protein Names:Maspin; Peptidase inhibitor 5; PI-5
Protein Family:Serpin
UniProt Gene Name:SERPINB5  
UniProt Entry Name:SPB5_HUMAN
Anti-SERPINB5 Antibody (CAB1179)Western blot analysis of extracts of various cell lines, using SERPINB5 antibody (CAB1179) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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