Cell Biology Antibodies 5
Anti-SERPINB4 Antibody (CAB15316)
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- SKU:
- CAB15316
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SERPINB4 Antibody |
| Antibody SKU: | CAB15316 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SERPINB4 (NP_002965.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SERPINB4 (NP_002965.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RTMG MVNI FNGD ADLS GMTW SHGL SVSK VLHK AFVE VTEE GVEA AAAT AVVV VELS SPST NEEF CCNH PFLF FIRQ NKTN SILF YGRF SSP |
| Gene ID: | 6318 |
| Uniprot: | P48594 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SERPINB4, LEUPIN, PI11, SCCA-2, SCCA1, SCCA2, serpin B4 |
| Background: | The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. |
| UniProt Protein Function: | SERPINB4: May act as a protease inhibitor to modulate the host immune response against tumor cells. Belongs to the serpin family. Ov-serpin subfamily. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 18q21.3 Cellular Component: extracellular space; intracellular Molecular Function:enzyme binding; protease binding; serine-type endopeptidase inhibitor activity Biological Process: negative regulation of peptidase activity; protection from natural killer cell mediated cytotoxicity |
| UniProt Code: | P48594 |
| NCBI GenInfo Identifier: | 1710877 |
| NCBI Gene ID: | 6318 |
| NCBI Accession: | P48594.2 |
| UniProt Secondary Accession: | P48594,A8K847, |
| UniProt Related Accession: | P48594 |
| Molecular Weight: | 44,854 Da |
| NCBI Full Name: | Serpin B4 |
| NCBI Synonym Full Names: | serpin family B member 4 |
| NCBI Official Symbol: | SERPINB4 |
| NCBI Official Synonym Symbols: | PI11; SCCA1; SCCA2; LEUPIN; SCCA-2 |
| NCBI Protein Information: | serpin B4 |
| UniProt Protein Name: | Serpin B4 |
| UniProt Synonym Protein Names: | Leupin; Peptidase inhibitor 11; PI-11; Squamous cell carcinoma antigen 2; SCCA-2 |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINB4 |
| UniProt Entry Name: | SPB4_HUMAN |
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