Cell Biology Antibodies 10
Anti-SERPINA7 Antibody (CAB6313)
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- SKU:
- CAB6313
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SERPINA7 Antibody |
| Antibody SKU: | CAB6313 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 146-415 of human SERPINA7 (NP_000345.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Muose heart, Mouse pancreas, Rat liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 146-415 of human SERPINA7 (NP_000345.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FLND VKTL YETE VFST DFSN ISAA KQEI NSHV EMQT KGKV VGLI QDLK PNTI MVLV NYIH FKAQ WANP FDPS KTED SSSF LIDK TTTV QVPM MHQM EQYY HLVD MELN CTVL QMDY SKNA LALF VLPK EGQM ESVE AAMS SKTL KKWN RLLQ KGWV DLFV PKFS ISAT YDLG ATLL KMGI QHAY SENA DFSG LTED NGLK LSNA AHKA VLHI GEKG TEAA AVPE VELS DQPE NTFL HPII QIDR SFML LILE RSTR SILF LGKV VNPT EA |
| Gene ID: | 6906 |
| Uniprot: | P05543 |
| Cellular Location: | Secreted |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | SERPINA7, TBG, TBGQTL |
| Background: | There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. |
| UniProt Protein Function: | SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: Xq22.2 Molecular Function:serine-type endopeptidase inhibitor activity |
| NCBI Summary: | There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012] |
| UniProt Code: | P05543 |
| NCBI GenInfo Identifier: | 1351236 |
| NCBI Gene ID: | 6906 |
| NCBI Accession: | P05543.2 |
| UniProt Secondary Accession: | P05543,D3DUX1, |
| UniProt Related Accession: | P05543 |
| Molecular Weight: | 46,325 Da |
| NCBI Full Name: | Thyroxine-binding globulin |
| NCBI Synonym Full Names: | serpin family A member 7 |
| NCBI Official Symbol: | SERPINA7 |
| NCBI Official Synonym Symbols: | TBG |
| NCBI Protein Information: | thyroxine-binding globulin |
| UniProt Protein Name: | Thyroxine-binding globulin |
| UniProt Synonym Protein Names: | Serpin A7; T4-binding globulin |
| Protein Family: | Thyroxine-binding globulin |
| UniProt Gene Name: | SERPINA7 |
| UniProt Entry Name: | THBG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINA7 antibody (CAB6313) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver using SERPINA7 antibody (CAB6313) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using SERPINA7 antibody (CAB6313) at dilution of 1:100 (40x lens). |
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