Cell Biology Antibodies 12
Anti-Serpin B6 Antibody (CAB9944)
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- SKU:
- CAB9944
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Serpin B6 Antibody |
| Antibody SKU: | CAB9944 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human SERPINB6 (NP_004559.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | SW620, HeLa, HepG2, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human SERPINB6 (NP_004559.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ENTE ERLF KVSK NEEK PVQM MFKQ STFK KTYI GEIF TQIL VLPY VGKE LNMI IMLP DETT DLRT VEKE LTYE KFVE WTRL DMMD EEEV EVSL PRFK LEES YDME SVLR NLGM TDAF ELGK A |
| Gene ID: | 5269 |
| Uniprot: | P35237 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 42kDa |
| Observed MW: | 43kDa |
| Synonyms: | SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin B6 |
| Background: | The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. |
| NCBI Summary: | The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | P35237 |
| NCBI GenInfo Identifier: | 425876796 |
| NCBI Gene ID: | 5269 |
| NCBI Accession: | NP_001182220.2 |
| UniProt Secondary Accession: | P35237,Q59F97, Q5TD06, Q7Z2Y7, Q96J44, Q9UDI7, B2RBA8 |
| UniProt Related Accession: | P35237 |
| Molecular Weight: | 42,622 Da |
| NCBI Full Name: | serpin B6 isoform b |
| NCBI Synonym Full Names: | serpin family B member 6 |
| NCBI Official Symbol: | SERPINB6 |
| NCBI Official Synonym Symbols: | CAP; PI6; PTI; PI-6; SPI3; DFNB91; MSTP057 |
| NCBI Protein Information: | serpin B6 |
| UniProt Protein Name: | Serpin B6 |
| UniProt Synonym Protein Names: | Cytoplasmic antiproteinase; CAP; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor |
| UniProt Gene Name: | SERPINB6 |
 | Western blot analysis of extracts of various cell lines, using SERPINB6 antibody (CAB9944) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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