Description
| Antibody Name: | Anti-SERCA2 Antibody |
| Antibody SKU: | CAB11692 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SERCA2 |
| Application: | WB IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, NIH/3T3, RD, Rat brain |
| Immunogen: | A synthesized peptide derived from human SERCA2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 488 |
| Uniprot: | P16615 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein, Sarcoplasmic reticulum membrane |
| Calculated MW: | 110, 140kDa |
| Observed MW: | 100KDa |
 | Western blot - SERCA2 Rabbit mAb (CAB11692) |
| Synonyms: | ATP2B, DAR, DD, SERCA2 |
| Background: | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008] |
| UniProt Protein Function: | SERCA2: an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Transporter, ion channel; EC 3.6.3.8; Endoplasmic reticulum; Cell adhesion; Hydrolase; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane Molecular Function:calcium ion binding; calcium-transporting ATPase activity; enzyme binding; protein binding Biological Process: cell adhesion; elevation of endoplasmic reticulum calcium ion concentration; endoplasmic reticulum calcium ion homeostasis; epidermis development; positive regulation of heart rate Disease: Acrokeratosis Verruciformis; Darier-white Disease |
| NCBI Summary: | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P16615 |
| NCBI GenInfo Identifier: | 114312 |
| NCBI Gene ID: | 488 |
| NCBI Accession: | P16615.1 |
| UniProt Secondary Accession: | P16615,P16614, Q86VJ2, A6NDN7, B4DF05, |
| UniProt Related Accession: | P16615 |
| Molecular Weight: | 109,734 Da |
| NCBI Full Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| NCBI Synonym Full Names: | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
| NCBI Official Symbol: | ATP2A2 |
| NCBI Official Synonym Symbols: | DD; DAR; ATP2B; SERCA2 |
| NCBI Protein Information: | sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| UniProt Protein Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| UniProt Synonym Protein Names: | Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase |
| Protein Family: | Sarcoplasmic/endoplasmic reticulum calcium ATPase |
| UniProt Gene Name: | ATP2A2 |
| UniProt Entry Name: | AT2A2_HUMAN |
