Cell Biology Antibodies 14
Anti-SEPW1 Antibody (CAB15014)
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- SKU:
- CAB15014
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SEPW1 Antibody |
| Antibody SKU: | CAB15014 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human SEPW1 (NP_003000.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human SEPW1 (NP_003000.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MALA VRVV YCGA UGYK SKYL QLKK KLED EFPG RLDI CGEG TPQA TGFF EVMV AGKL IHSK KKGD GYVD TESK FLKL VAAI KAAL AQG |
| Gene ID: | 6415 |
| Uniprot: | P63302 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 9kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SELENOW, SEPW1, selW |
| Background: | This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. |
| UniProt Protein Function: | SEPW1: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency. Belongs to the SelWTH family. SELW subfamily. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: cytoplasm Molecular Function:antioxidant activity; selenium binding Biological Process: cell redox homeostasis |
| NCBI Summary: | This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P63302 |
| NCBI GenInfo Identifier: | 4506887 |
| NCBI Gene ID: | 6415 |
| NCBI Accession: | NP_003000.1 |
| UniProt Secondary Accession: | P63302,O15532, O19096, Q86TI9, Q96KM5, A8MRR7, |
| UniProt Related Accession: | P63302 |
| Molecular Weight: | 9,448 Da |
| NCBI Full Name: | selenoprotein W |
| NCBI Synonym Full Names: | selenoprotein W, 1 |
| NCBI Official Symbol: | SEPW1 |
| NCBI Official Synonym Symbols: | selW |
| NCBI Protein Information: | selenoprotein W |
| UniProt Protein Name: | Selenoprotein W |
| Protein Family: | Selenoprotein |
| UniProt Gene Name: | SEPW1 |
| UniProt Entry Name: | SELW_HUMAN |
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