Cell Biology Antibodies 15
Anti-SEPT6 Antibody (CAB8196)
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- SKU:
- CAB8196
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
| Antibody Name: | Anti-SEPT6 Antibody |
| Antibody SKU: | CAB8196 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-434 of human SEPT6 (NP_055944.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-434 of human SEPT6 (NP_055944.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VKEK EAEL KEAE KELH EKFD RLKK LHQD EKKK LEDK KKSL DDEV NAFK QRKT AAEL LQSQ GSQA GGSQ TLKR DKEK KNNP WLCT E |
| Gene ID: | 23157 |
| Uniprot: | Q14141 |
| Cellular Location: | Chromosome, Cleavage furrow, Cytoplasm, Midbody, centromere, cytoskeleton, kinetochore, spindle |
| Calculated MW: | 29kDa/48kDa/49kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SEPT6, SEP2, SEPT2, septin-6 |
| Background: | This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. |
| UniProt Protein Function: | SEPT6: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Belongs to the septin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Hydrolase Chromosomal Location of Human Ortholog: Xq24 Molecular Function:GTP binding; protein binding Biological Process: cytokinesis |
| NCBI Summary: | This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14141 |
| NCBI GenInfo Identifier: | 20178343 |
| NCBI Gene ID: | 23157 |
| NCBI Accession: | Q14141.4 |
| UniProt Secondary Accession: | Q14141,Q5JTK0, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87 |
| UniProt Related Accession: | Q14141 |
| Molecular Weight: | 49,167 Da |
| NCBI Full Name: | Septin-6 |
| NCBI Synonym Full Names: | septin 6 |
| NCBI Official Symbol: | SEPT6 |
| NCBI Official Synonym Symbols: | SEP2; SEPT2 |
| NCBI Protein Information: | septin-6 |
| UniProt Protein Name: | Septin-6 |
| UniProt Gene Name: | SEPT6 |
| UniProt Entry Name: | SEPT6_HUMAN |
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