Cell Cycle Antibodies 1

Anti-SEPT2 Antibody (CAB5801)

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SKU:
CAB5801
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-SEPT2 Antibody
Antibody SKU:CAB5801
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 112-361 of human SEPT2 (NP_004395.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:293T, HepG2, MCF7, HeLa, BT-474, BxPC-3, Mouse spleen, Mouse lung, Mouse ovary
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 112-361 of human SEPT2 (NP_004395.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RDCF KTII SYID EQFE RYLH DESG LNRR HIID NRVH CCFY FISP FGHG LKPL DVAF MKAI HNKV NIVP VIAK ADTL TLKE RERL KKRI LDEI EEHN IKIY HLPD AESD EDED FKEQ TRLL KASI PFSV VGSN QLIE AKGK KVRG RLYP WGVV EVEN PEHN DFLK LRTM LITH MQDL QEVT QDLH YENF RSER LKRG GRKV ENED MNKD QILL EKEA ELRR MQEM IARM QAQM QMQM QGGD GDGG ALGH HV
Gene ID:4735
Uniprot:Q15019
Cellular Location:Cell projection, Chromosome, Cleavage furrow, Cytoplasm, Midbody, cell cortex, centromere, cilium membrane, cytoskeleton, kinetochore, spindle
Calculated MW:41kDa/42kDa/45kDa
Observed MW:41kDa
Synonyms:SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5, septin-2
Background:
UniProt Protein Function:SEPT2: a member of the septin family of proteins. May be involved in the process of cytokinesis. Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell.
UniProt Protein Details:

Protein type:Cytoskeletal; Hydrolase; Cell development/differentiation; Motility/polarity/chemotaxis; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; exocyst; synapse; spindle; midbody; cell cortex; nucleus; actin cytoskeleton; cleavage furrow

Molecular Function:protein binding; GTP binding; protein complex scaffold; enzyme regulator activity

Biological Process: mitosis; smoothened signaling pathway; regulation of protein localization; regulation of catalytic activity; cell division; cilium biogenesis; regulation of L-glutamate transport; neurite development

UniProt Code:Q15019
NCBI GenInfo Identifier:2500769
NCBI Gene ID:4735
NCBI Accession:Q15019.1
UniProt Secondary Accession:Q15019,Q14132, Q53QU3, Q8IUK9, Q96CB0, B4DGE8,
UniProt Related Accession:Q15019
Molecular Weight:361
NCBI Full Name:Septin-2
NCBI Synonym Full Names:septin 2
NCBI Official Symbol:SEPT2  
NCBI Official Synonym Symbols:DIFF6; NEDD5; NEDD-5; Pnutl3; hNedd5  
NCBI Protein Information:septin-2; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed developmentally down-regulated protein 5
UniProt Protein Name:Septin-2
UniProt Synonym Protein Names:Neural precursor cell expressed developmentally down-regulated protein 5; NEDD-5
UniProt Gene Name:SEPT2  
UniProt Entry Name:SEPT2_HUMAN
Anti-SEPT2 Antibody (CAB5801)Western blot analysis of extracts of various cell lines, using SEPT2 antibody (CAB5801) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-SEPT2 Antibody (CAB5801)Immunofluorescence analysis of U2OS cells using SEPT2 antibody (CAB5801). Blue: DAPI for nuclear staining.
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