Cell Cycle Antibodies 1

Anti-SEPT11 Antibody (CAB12189)

(No reviews yet) Write a Review
SKU:
CAB12189
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SEPT11 Antibody
Antibody SKU:CAB12189
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SEPT11 (NP_060713.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, 293T, A-431, HeLa, Mouse liver, Rat brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SEPT11 (NP_060713.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAVA VGRP SNEE LRNL SLSG HVGF DSLP DQLV NKST SQGF CFNI LCVG ETGI GKST LMDT LFNT KFES DPAT HNEP GVRL KARS YELQ ESNV RLKL TIVD TVGF GDQI NKDD SYKP IVEY
Gene ID:55752
Uniprot:Q9NVA2
Cellular Location:Cell junction, Cell projection, Cytoplasm, axon, cytoskeleton, dendritic spine, synapse
Calculated MW:49kDa/50kDa
Observed MW:49kDa
Synonyms:SEPT11, septin-11
Background:
UniProt Protein Function:SEPT11: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with MLL/HRX. Belongs to the septin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; Cytoskeletal; Hydrolase; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: stress fiber

Molecular Function:protein binding

Biological Process: protein heterooligomerization

NCBI Summary:SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]
UniProt Code:Q9NVA2
NCBI GenInfo Identifier:50401687
NCBI Gene ID:55752
NCBI Accession:Q9NVA2.3
UniProt Secondary Accession:Q9NVA2,Q4W5G1, Q7L4N1, Q96SP1, Q9UFY9, B7Z7Z6, E9KL32
UniProt Related Accession:Q9NVA2
Molecular Weight:49kDa
NCBI Full Name:Septin-11
NCBI Synonym Full Names:septin 11
NCBI Official Symbol:SEPT11  
NCBI Protein Information:septin-11
UniProt Protein Name:Septin-11
UniProt Gene Name:SEPT11  
Anti-SEPT11 Antibody (CAB12189)Western blot analysis of extracts of various cell lines, using SEPT11 antibody (CAB12189) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
View AllClose

0 Reviews

View AllClose

Related Products