Cell Cycle Antibodies 1
Anti-SEPT11 Antibody (CAB12040)
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- SKU:
- CAB12040
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-SEPT11 Antibody |
| Antibody SKU: | CAB12040 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SEPT11 (NP_060713.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SEPT11 (NP_060713.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAVA VGRP SNEE LRNL SLSG HVGF DSLP DQLV NKST SQGF CFNI LCVG ETGI GKST LMDT LFNT KFES DPAT HNEP GVRL KARS YELQ ESNV RLKL TIVD TVGF GDQI NKDD SYKP IVEY |
| Gene ID: | 55752 |
| Uniprot: | Q9NVA2 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, axon, cytoskeleton, dendritic spine, synapse |
| Calculated MW: | 49kDa/50kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SEPT11, septin-11 |
| Background: |
| UniProt Protein Function: | SEPT11: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with MLL/HRX. Belongs to the septin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal; Hydrolase; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q21.1 Cellular Component: stress fiber Molecular Function:protein binding Biological Process: protein heterooligomerization |
| NCBI Summary: | SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009] |
| UniProt Code: | Q9NVA2 |
| NCBI GenInfo Identifier: | 50401687 |
| NCBI Gene ID: | 55752 |
| NCBI Accession: | Q9NVA2.3 |
| UniProt Secondary Accession: | Q9NVA2,Q4W5G1, Q7L4N1, Q96SP1, Q9UFY9, B7Z7Z6, E9KL32 |
| UniProt Related Accession: | Q9NVA2 |
| Molecular Weight: | 49kDa |
| NCBI Full Name: | Septin-11 |
| NCBI Synonym Full Names: | septin 11 |
| NCBI Official Symbol: | SEPT11 |
| NCBI Protein Information: | septin-11 |
| UniProt Protein Name: | Septin-11 |
| UniProt Gene Name: | SEPT11 |
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