Signal Transduction Antibodies 1
Anti-SENP8 Antibody (CAB12753)
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- SKU:
- CAB12753
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SENP8 Antibody |
| Antibody SKU: | CAB12753 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human SENP8 (NP_660205.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | 293T, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human SENP8 (NP_660205.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPV VLSY MDSL LRQS DVSL LDPP SWLN DHII GFAF EYFA NSQF HDCS DHVS FISP EVTQ FIKC TSNP AEIA MFLE PLDL PNKR VVFL AIND NSNQ AAGG THWS LLVY LQDK NSFF HYDS HSRS NSVH AKQV AEKL EAFL GRKG DKLA FVEE KAPA QQNS YDCG MYVI CNTE ALCQ NFFR QQTE SLLQ LLTP AYIT KKRG EWKD LITT LAKK |
| Gene ID: | 123228 |
| Uniprot: | Q96LD8 |
| Cellular Location: | |
| Calculated MW: | 24kDa |
| Observed MW: | 24kDa |
| Synonyms: | SENP8, DEN1, NEDP1, PRSC2 |
| Background: | This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | SENP8: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Belongs to the peptidase C48 family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.68; Protease Chromosomal Location of Human Ortholog: 15q23 Cellular Component: cytosol; nucleus Molecular Function:endopeptidase activity; NEDD8-specific protease activity; SUMO-specific protease activity Biological Process: protein desumoylation; protein deubiquitination |
| NCBI Summary: | This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q96LD8 |
| NCBI GenInfo Identifier: | 26006881 |
| NCBI Gene ID: | 123228 |
| NCBI Accession: | Q96LD8.1 |
| UniProt Secondary Accession: | Q96LD8,Q96QA4, |
| UniProt Related Accession: | Q96LD8 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Sentrin-specific protease 8 |
| NCBI Synonym Full Names: | SUMO/sentrin peptidase family member, NEDD8 specific |
| NCBI Official Symbol: | SENP8 |
| NCBI Official Synonym Symbols: | DEN1; NEDP1; PRSC2 |
| NCBI Protein Information: | sentrin-specific protease 8 |
| UniProt Protein Name: | Sentrin-specific protease 8 |
| UniProt Synonym Protein Names: | Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP8 |
 | Western blot analysis of extracts of various cell lines, using SENP8 antibody (CAB12753) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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