Cell Biology Antibodies 13
Anti-SENP6 Antibody (CAB17673)
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- SKU:
- CAB17673
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SENP6 Antibody |
| Antibody SKU: | CAB17673 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 811-1112 of human SENP6 (NP_056386.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat thymus, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 811-1112 of human SENP6 (NP_056386.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESC SQNS SAKP VIKK MLNK KHCI AVID SNPG QEES DPRY KRNI CSVK YSVK KINH TASE NEEF NKGE STSQ KVAD RTKS ENGL QNES LSST HHTD GLSK IRLN YSDE SPEA GKML EDEL VDFS EDQD NQDD SSDD GFLA DDNC SSEI GQWH LKPT ICKQ PCIL LMDS LRGP SRSN VVKI LREY LEVE WEVK KGSK RSFS KDVM KGSN PKVP QQNN FSDC GVYV LQYV ESFF ENPI LSFE LPMN LANW FPPP RMRT KREE IRNI ILKL QEDQ SKEK RKHK DTYS TEAP LGEG TEQY VNSI SD |
| Gene ID: | 26054 |
| Uniprot: | Q9GZR1 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 126kDa |
 | Western blot - SENP6 Polyclonal Antibody (CAB17673) |
| Synonyms: | SSP1, SUSP1, SENP6 |
| Background: | Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] |
| UniProt Protein Function: | SENP6: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.22.68 Chromosomal Location of Human Ortholog: 6q14.1 Cellular Component: cytoplasm; nucleoplasm Molecular Function:protein binding; SUMO-specific protease activity Biological Process: protein desumoylation |
| NCBI Summary: | Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q9GZR1 |
| NCBI GenInfo Identifier: | 119370526 |
| NCBI Gene ID: | 26054 |
| NCBI Accession: | Q9GZR1.2 |
| UniProt Secondary Accession: | Q9GZR1,O94891, Q5VUL3, Q5VUL4, Q8TBY4, Q9UJV5, A6NNY9 |
| UniProt Related Accession: | Q9GZR1 |
| Molecular Weight: | 125,330 Da |
| NCBI Full Name: | Sentrin-specific protease 6 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 6 |
| NCBI Official Symbol: | SENP6 |
| NCBI Official Synonym Symbols: | SSP1; SUSP1 |
| NCBI Protein Information: | sentrin-specific protease 6 |
| UniProt Protein Name: | Sentrin-specific protease 6 |
| UniProt Synonym Protein Names: | SUMO-1-specific protease 1; Sentrin/SUMO-specific protease SENP6 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP6 |
| UniProt Entry Name: | SENP6_HUMAN |
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