Cell Biology Antibodies 17

Anti-SENP3 Antibody (CAB18448)

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SKU:
CAB18448
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SENP3 Antibody
Antibody SKU:CAB18448
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SENP3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human SENP3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26168
Uniprot:Q9H4L4
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:SMT3IP1, SSP3, Ulp1, SENP3
Background:
UniProt Protein Function:SENP3: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Binds to SUMO1 and SUMO3. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm. Belongs to the peptidase C48 family.
UniProt Protein Details:

Protein type:Protease; EC 3.4.22.68; Nucleolus; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: protein desumoylation; rRNA processing

NCBI Summary:The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
UniProt Code:Q9H4L4
NCBI GenInfo Identifier:119370525
NCBI Gene ID:26168
NCBI Accession:Q9H4L4.2
UniProt Secondary Accession:Q9H4L4,Q66K15, Q86VS7, Q96PS4, Q9Y3W9,
UniProt Related Accession:Q9H4L4
Molecular Weight:65,010 Da
NCBI Full Name:Sentrin-specific protease 3
NCBI Synonym Full Names:SUMO1/sentrin/SMT3 specific peptidase 3
NCBI Official Symbol:SENP3  
NCBI Official Synonym Symbols:SSP3; Ulp1; SMT3IP1  
NCBI Protein Information:sentrin-specific protease 3
UniProt Protein Name:Sentrin-specific protease 3
UniProt Synonym Protein Names:SUMO-1-specific protease 3; Sentrin/SUMO-specific protease SENP3
Protein Family:Sentrin-specific protease
UniProt Gene Name:SENP3  
UniProt Entry Name:SENP3_HUMAN
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