Signal Transduction Antibodies 3
Anti-SENP1 Antibody (CAB4460)
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- SKU:
- CAB4460
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SuPr-2
Description
| Product Name: | SENP1 Rabbit mAb |
| Product Code: | CAB4460 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | SuPr-2 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SENP1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, PC-3 |
| Immunogen: | A synthesized peptide derived from human SENP1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 29843 |
| Uniprot: | Q9P0U3 |
| Calculated MW: | 73kDa |
| Observed MW: | 73KDa |
| UniProt Protein Function: | SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.68; Protease; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis |
| NCBI Summary: | This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q9P0U3 |
| NCBI GenInfo Identifier: | 215273882 |
| NCBI Gene ID: | 29843 |
| NCBI Accession: | Q9P0U3.2 |
| UniProt Secondary Accession: | Q9P0U3,Q86XC8, A8K7P5, |
| UniProt Related Accession: | Q9P0U3 |
| Molecular Weight: | 73,351 Da |
| NCBI Full Name: | Sentrin-specific protease 1 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 1 |
| NCBI Official Symbol: | SENP1 |
| NCBI Official Synonym Symbols: | SuPr-2 |
| NCBI Protein Information: | sentrin-specific protease 1 |
| UniProt Protein Name: | Sentrin-specific protease 1 |
| UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP1 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP1 |
| UniProt Entry Name: | SENP1_HUMAN |
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