Signal Transduction Antibodies 1
Anti-SENP1 Antibody (CAB13086)
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- SKU:
- CAB13086
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SENP1 Antibody |
| Antibody SKU: | CAB13086 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SENP1 (NP_001254523.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, HT-29, HepG2, HeLa, Mouse testis, Mouse thymus, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SENP1 (NP_001254523.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SRCL SSSK NTLK DSLF KNGN SCAS QIIG SDTS SSGS ASIL TNQE QLSH SVYS LSSY TPDV AFGS KDSG TLHH PHHH HSVP HQPD NLAA SNTQ SEGS DSVI LLKV KDSQ TPTP SSTF FQAE LWIK ELTS VYDS RARE RLRQ IEEQ KALA LQLQ NQRL QERE HSVH DSVE LHLR VPLE KEIP VTVV QETQ KKGH KLTD SEDE F |
| Gene ID: | 29843 |
| Uniprot: | Q9P0U3 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 73kDa |
| Observed MW: | 73kDa |
| Synonyms: | SENP1, SuPr-2 |
| Background: | This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.68; Protease; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis |
| NCBI Summary: | This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q9P0U3 |
| NCBI GenInfo Identifier: | 215273882 |
| NCBI Gene ID: | 29843 |
| NCBI Accession: | Q9P0U3.2 |
| UniProt Secondary Accession: | Q9P0U3,Q86XC8, A8K7P5, |
| UniProt Related Accession: | Q9P0U3 |
| Molecular Weight: | 73,351 Da |
| NCBI Full Name: | Sentrin-specific protease 1 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 1 |
| NCBI Official Symbol: | SENP1 |
| NCBI Official Synonym Symbols: | SuPr-2 |
| NCBI Protein Information: | sentrin-specific protease 1 |
| UniProt Protein Name: | Sentrin-specific protease 1 |
| UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP1 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP1 |
| UniProt Entry Name: | SENP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SENP1 antibody (CAB13086) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Mouse testis using SENP1 Rabbit pAb (CAB13086) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat testis using SENP1 Rabbit pAb (CAB13086) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human liver cancer using SENP1 Rabbit pAb (CAB13086) at dilution of 1:100 (40x lens). |
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