Developmental Biology
Anti-SEMA3A Antibody (CAB5700)
- SKU:
- CAB5700
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Antibody Name: | Anti-SEMA3A Antibody |
Antibody SKU: | CAB5700 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human SEMA3A (NP_006071.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Rat |
Positive Samples: | Rat brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human SEMA3A (NP_006071.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | ANYQ NGKN NVPR LKLS YKEM LESN NVIT FNGL ANSS SYHT FLLD EERS RLYV GAKD HIFS FDLV NIKD FQKI VWPV SYTR RDEC KWAG KDIL KECA NFIK VLKA YNQT HLYA CGTG AFHP ICTY IEIG HHPE DNIF KLEN SHFE NGRG KSPY DPKL LTAS LLID GELY SGTA ADFM GRDF AIFR TLGH HHPI RTEQ HDSR WLND PKFI SAHL ISES DNPE DDKV YFFF RENA IDGE HSGK ATHA RIGQ ICK |
Gene ID: | 10371 |
Uniprot: | Q14563 |
Cellular Location: | Secreted |
Calculated MW: | 88kDa |
Observed MW: | 89KDa |
Synonyms: | SEMA3A, COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1 |
Background: | This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. |
UniProt Protein Function: | SEMA3A: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. Belongs to the semaphorin family. |
UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7p12.1 Cellular Component: axon; extracellular region; extracellular space Molecular Function:chemorepellent activity; semaphorin receptor binding Biological Process: axon extension involved in axon guidance; axon guidance; negative regulation of axon extension involved in axon guidance; nerve development; neural crest cell migration; neuron migration; olfactory bulb development; regulation of axon extension involved in axon guidance; sensory system development; sympathetic nervous system development Disease: Hypogonadotropic Hypogonadism 16 With Or Without Anosmia |
NCBI Summary: | This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14563 |
NCBI GenInfo Identifier: | 8134674 |
NCBI Gene ID: | 10371 |
NCBI Accession: | Q14563.1 |
UniProt Related Accession: | Q14563 |
Molecular Weight: | |
NCBI Full Name: | Semaphorin-3A |
NCBI Synonym Full Names: | semaphorin 3A |
NCBI Official Symbol: | SEMA3A |
NCBI Official Synonym Symbols: | HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III |
NCBI Protein Information: | semaphorin-3A |
UniProt Protein Name: | Semaphorin-3A |
UniProt Synonym Protein Names: | Semaphorin III; Sema III |
Protein Family: | Semaphorin |
UniProt Gene Name: | SEMA3A |
UniProt Entry Name: | SEM3A_HUMAN |
View AllClose