Cell Biology Antibodies 7

Anti-SELENOM Antibody (CAB16660)

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SKU:
CAB16660
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SELENOM Antibody
Antibody SKU:CAB16660
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-130 of human SELENOM (NP_536355.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, A-431, Mouse kidney, Mouse heart, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-130 of human SELENOM (NP_536355.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LNRL KEVK AFVT QDIP FYHN LVMK HLPG ADPE LVLL GRRY EELE RIPL SEMT REEI NALV QELG FYRK AAPD AQVP PEYV W
Gene ID:140606
Uniprot:Q8WWX9
Cellular Location:
Calculated MW:16kDa
Observed MW:16kDa
Synonyms:SELENOM, SELM, SEPM
Background:The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.
UniProt Protein Function:SELM: May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. Belongs to the selenoprotein M/SEP15 family.
UniProt Protein Details:

Protein type:Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm

NCBI Summary:This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WWX9
NCBI GenInfo Identifier:17975597
NCBI Gene ID:140606
NCBI Accession:NP_536355.1
UniProt Secondary Accession:Q8WWX9,A8MPZ2,
UniProt Related Accession:Q8WWX9
Molecular Weight:17.9 kDa
NCBI Full Name:selenoprotein M
NCBI Official Symbol:SELM  
NCBI Official Synonym Symbols:SEPM  
NCBI Protein Information:selenoprotein M; selenoprotein SelM
UniProt Protein Name:Selenoprotein M
Protein Family:Selenoprotein
UniProt Gene Name:SELM  
UniProt Entry Name:SELM_HUMAN
Anti-SELENOM Antibody (CAB16660)Western blot analysis of extracts of various cell lines, using SELENOM antibody (CAB16660) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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