Anti-SELENOK Antibody (CAB20560)

(No reviews yet) Write a Review
SKU:
CAB20560
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SELK
Synonyms:
HSPC030
Synonyms:
HSPC297

Description

Product Name:SELENOK Rabbit pAb
Product Code:CAB20560
Size:50uL, 100uL
Synonyms:SELK, HSPC030, HSPC297
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human SELENOK.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse spleen, Mouse heart
Immunogen:Recombinant protein of human SELENOK.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:58515
Uniprot:Q9Y6D0
Calculated MW:10kDa
Observed MW:11KDa
Background:The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.
View AllClose

0 Reviews

View AllClose

Related Products