Signal Transduction Antibodies 1
Anti-SEL1L Antibody (CAB12073)
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- SKU:
- CAB12073
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SEL1L Antibody |
| Antibody SKU: | CAB12073 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, HepG2, 293T, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SSDE EGSQ DESL DSKT TLTS DESV KDHT TAGR VVAG QIFL DSEE SELE SSIQ EEED SLKS QEGE SVTE DISF LESP NPEN KDYE EPKK VRKP ALTA IEGT AHGE PCHF PFLF LDKE YDEC TSDG REDG RLWC ATTY DYKA DEKW GFCE TEEE AAKR RQMQ EAEM MYQT G |
| Gene ID: | 6400 |
| Uniprot: | Q9UBV2 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
| Calculated MW: | 33kDa/88kDa |
| Observed MW: | 102kDa |
| Synonyms: | SEL1L, PRO1063, SEL1-LIKE, SEL1L1 |
| Background: | The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SEL1L: May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Belongs to the sel-1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q31 Cellular Component: endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: ER-associated protein catabolic process; protein stabilization; retrograde protein transport, ER to cytosol |
| NCBI Summary: | The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UBV2 |
| NCBI GenInfo Identifier: | 62512184 |
| NCBI Gene ID: | 6400 |
| NCBI Accession: | Q9UBV2.3 |
| UniProt Secondary Accession: | Q9UBV2,Q6UWT6, Q9P1T9, Q9UHK7, |
| UniProt Related Accession: | Q9UBV2 |
| Molecular Weight: | 33,530 Da |
| NCBI Full Name: | Protein sel-1 homolog 1 |
| NCBI Synonym Full Names: | SEL1L ERAD E3 ligase adaptor subunit |
| NCBI Official Symbol: | SEL1L |
| NCBI Official Synonym Symbols: | SEL1L1; PRO1063; SEL1-LIKE |
| NCBI Protein Information: | protein sel-1 homolog 1 |
| UniProt Protein Name: | Protein sel-1 homolog 1 |
| UniProt Synonym Protein Names: | Suppressor of lin-12-like protein 1; Sel-1L |
| Protein Family: | Protein |
| UniProt Gene Name: | SEL1L |
| UniProt Entry Name: | SE1L1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SEL1L antibody (CAB12073) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunofluorescence analysis of C6 cells using SEL1L antibody (CAB12073) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SEL1L antibody (CAB12073) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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