Cell Biology Antibodies 6
Anti-SEC23IP Antibody (CAB15398)
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- SKU:
- CAB15398
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SEC23IP Antibody |
| Antibody SKU: | CAB15398 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-940 of human SEC23IP (NP_009121.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-940 of human SEC23IP (NP_009121.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NLSK CPGP LAVA NGVV KQLH FQEK QMPE EPKL TLDE SYDL VVEN KEVL TLQE TLEA LSLS EYFS TFEK EKID MESL LMCT VDDL KEMG IPLG PRKK IANF VEHK AAKL KKAA SEKK AVAA TSTK GQEQ SAQK TKDM ASLP SESN EPKR KLPV GACV SSVC VNYE SFEV GAGQ VSVA YNSL DFEP EIFF ALGS PIAM FLTI RGVD RIDE NYSL PTCK GFFN IYHP LDPV AYRL EPMI VPDL DLKA VLIP HHKG RKRL HLEL KESL SRMG SDLK QGFI SSLK SAWQ TLNE FARA HTSS TQLQ EELE KVAN QIKE EEEK QVVE AEKV VESP DFSK DEDY LGKV G |
| Gene ID: | 11196 |
| Uniprot: | Q9Y6Y8 |
| Cellular Location: | COPII-coated vesicle membrane, Cytoplasmic side, Cytoplasmic vesicle, Endoplasmic reticulum, Peripheral membrane protein |
| Calculated MW: | 102kDa/111kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SEC23IP, MSTP053, P125, P125A |
| Background: | This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. |
| UniProt Protein Function: | SEC23IP: Plays a role in the organization of endoplasmic reticulum exit sites. Belongs to the PA-PLA1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 10q25-q26 Cellular Component: cis-Golgi network; intracellular membrane-bound organelle; cytoplasm; ER-Golgi intermediate compartment Molecular Function:metal ion binding Biological Process: acrosome formation; intracellular protein transport; single fertilization; Golgi organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q9Y6Y8 |
| NCBI GenInfo Identifier: | 55584014 |
| NCBI Gene ID: | 11196 |
| NCBI Accession: | Q9Y6Y8.1 |
| UniProt Related Accession: | Q9Y6Y8 |
| Molecular Weight: | 102kDa; 111kDa |
| NCBI Full Name: | SEC23-interacting protein |
| NCBI Synonym Full Names: | SEC23 interacting protein |
| NCBI Official Symbol: | SEC23IP |
| NCBI Official Synonym Symbols: | P125; P125A; MSTP053 |
| NCBI Protein Information: | SEC23-interacting protein |
| UniProt Protein Name: | SEC23-interacting protein |
| UniProt Synonym Protein Names: | p125 |
| Protein Family: | SEC23-interacting protein |
| UniProt Gene Name: | SEC23IP |
| UniProt Entry Name: | S23IP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SEC23IP antibody (CAB15398) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded Human liver cancer using SEC23IP Rabbit pAb (CAB15398) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using SEC23IP antibody (CAB15398) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using SEC23IP antibody (CAB15398) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SEC23IP antibody (CAB15398) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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