Cell Biology Antibodies 6

Anti-SDHAF2 Antibody (CAB16204)

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SKU:
CAB16204
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SDHAF2 Antibody
Antibody SKU:CAB16204
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human SDHAF2 (NP_060311.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, mouse kidney, mouse stomach, mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human SDHAF2 (NP_060311.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAVS TVFS TSSL MLAL SRHS LLSP LLSV TSFR RFYR GDSP TDSQ KDMI EIPL PPWQ ERTD ESIE TKRA RLLY ESRK RGML ENCI LLSL FAKE HLQH MTEK QLNL YDRL INEP SNDW DIYY WATE AKPA PEIF ENEV MALL RDFA KNKN KEQR LRAP DLEY LFEK PR
Gene ID:54949
Uniprot:Q9NX18
Cellular Location:
Calculated MW:19kDa
Observed MW:15kDa
Synonyms:SDHAF2, C11orf79, PGL2, SDH5
Background:This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.
UniProt Protein Function:SDH5: a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function:protein binding

Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; protein amino acid dephosphorylation

Disease: Paragangliomas 2

NCBI Summary:This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]
UniProt Code:Q9NX18
NCBI GenInfo Identifier:8923450
NCBI Gene ID:54949
NCBI Accession:NP_060311.1
UniProt Related Accession:Q9NX18
Molecular Weight:19,599 Da
NCBI Full Name:succinate dehydrogenase assembly factor 2, mitochondrial
NCBI Synonym Full Names:succinate dehydrogenase complex assembly factor 2
NCBI Official Symbol:SDHAF2  
NCBI Official Synonym Symbols:PGL2; SDH5; C11orf79  
NCBI Protein Information:succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2; hSDH5; succinate dehydrogenase subunit 5, mitochondrial
UniProt Protein Name:Succinate dehydrogenase assembly factor 2, mitochondrial
Protein Family:Succinate dehydrogenase assembly factor
UniProt Gene Name:SDHAF2  
UniProt Entry Name:SDHF2_HUMAN
Anti-SDHAF2 Antibody (CAB16204)Western blot analysis of extracts of various cell lines, using SDHAF2 antibody (CAB16204) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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