Cell Biology Antibodies 14
Anti-SDHA Antibody (CAB13852)
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- SKU:
- CAB13852
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SDHA Antibody |
| Antibody SKU: | CAB13852 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SDHA |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, MCF7, Mouse liver, Mouse brain, Mouse heart, Rat brain, Rat heart |
| Immunogen: | A synthesized peptide derived from human SDHA |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6389 |
| Uniprot: | P31040 |
| Cellular Location: | |
| Calculated MW: | 72kDa |
| Observed MW: | 70KDa |
 | Western blot - SDHA Rabbit mAb (CAB13852) |
| Synonyms: | CMD1GG, FP, PGL5, SDH1, SDH2, SDHF |
| Background: | This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| UniProt Protein Function: | SDHA: is the catalytic subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. Complex II contains four subunits: the flavoprotein catalytic subunit SDHA, iron-sulfur protein SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interaction with SDH5 is required for FAD attachment. Responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHA cause defective mitochondrial oxidative phosphorylation, giving rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. Acetylation of SDHA may control entry of the substrate into the active site, thus regulating its enzymatic activity. Acetylated SDHA may be a SIRT3 substrate SIRT3 is a mitochondrial NAD(+)-dependent deacetylase. Increased succinate levels as a consequence of SDH deficiency inhibit hypoxia inducible factor-1alpha (HIF-1alpha) prolyl hydroxylases leading to sustained HIF-1alpha expression in tumours. Defects in SDHA cause of Leigh syndrome, a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. |
| UniProt Protein Details: | Protein type:Mitochondrial; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Oxidoreductase; Tumor suppressor; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 5p15 Cellular Component: mitochondrial respiratory chain complex II; mitochondrion; mitochondrial inner membrane Molecular Function:protein binding; succinate dehydrogenase (ubiquinone) activity; FAD binding; succinate dehydrogenase activity Biological Process: succinate metabolic process; cellular metabolic process; nervous system development; tricarboxylic acid cycle Disease: Mitochondrial Complex Ii Deficiency; Leigh Syndrome; Paragangliomas 5; Cardiomyopathy, Dilated, 1gg |
| NCBI Summary: | This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| UniProt Code: | P31040 |
| NCBI GenInfo Identifier: | 1169337 |
| NCBI Gene ID: | 6389 |
| NCBI Accession: | P31040.2 |
| UniProt Related Accession: | P31040 |
| Molecular Weight: | |
| NCBI Full Name: | Succinate dehydrogenase |
| NCBI Synonym Full Names: | succinate dehydrogenase complex flavoprotein subunit A |
| NCBI Official Symbol: | SDHA |
| NCBI Official Synonym Symbols: | FP; PGL5; SDH1; SDH2; SDHF; CMD1GG |
| NCBI Protein Information: | succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| UniProt Protein Name: | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| UniProt Synonym Protein Names: | Flavoprotein subunit of complex II; Fp |
| Protein Family: | Succinate dehydrogenase |
| UniProt Gene Name: | SDHA |
| UniProt Entry Name: | SDHA_HUMAN |
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