Cell Biology Antibodies 10
Anti-SCO1 Antibody (CAB6734)
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- SKU:
- CAB6734
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SCO1 Antibody |
| Antibody SKU: | CAB6734 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SCO1 (NP_004580.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, U-251MG, U-937, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SCO1 (NP_004580.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAML VLVP GRVM RPLG GQLW RFLP RGLE FWGP AEGT ARVL LRQF CARQ AEAW RASG RPGY CLGT RPLS TARP PPPW SQKG PGDS TRPS KPGP VSWK SLAI TFAI GGAL LAGM KHVK KEKA EKLE KERQ RHIG KPLL GGPF SLTT HTGE RKTD KDYL GQWL |
| Gene ID: | 6341 |
| Uniprot: | O75880 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 33kDa |
| Observed MW: | 34kDa |
| Synonyms: | SCO1, SCOD1 |
| Background: | Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. |
| UniProt Protein Function: | SCO1: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX. Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the SCO1/2 family. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: mitochondrion; myofibril; mitochondrial inner membrane Molecular Function:copper ion binding Biological Process: generation of precursor metabolites and energy; cellular copper ion homeostasis; respiratory chain complex IV assembly; copper ion transport Disease: Mitochondrial Complex Iv Deficiency |
| NCBI Summary: | Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75880 |
| NCBI GenInfo Identifier: | 8134663 |
| NCBI Gene ID: | 6341 |
| NCBI Accession: | O75880.1 |
| UniProt Secondary Accession: | O75880,B2RDM0, |
| UniProt Related Accession: | O75880 |
| Molecular Weight: | 33,814 Da |
| NCBI Full Name: | Protein SCO1 homolog, mitochondrial |
| NCBI Synonym Full Names: | SCO1 cytochrome c oxidase assembly protein |
| NCBI Official Symbol: | SCO1 |
| NCBI Official Synonym Symbols: | SCOD1 |
| NCBI Protein Information: | protein SCO1 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 1 |
| UniProt Protein Name: | Protein SCO1 homolog, mitochondrial |
| Protein Family: | SCO1 protein |
| UniProt Gene Name: | SCO1 |
| UniProt Entry Name: | SCO1_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver using SCO1 antibody (CAB6734) at dilution of 1:100 (40x lens). |
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