Signal Transduction Antibodies 3

Anti-SCNN1G Antibody (CAB6126)

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SKU:
CAB6126
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SCNN1G Antibody
Antibody SKU:CAB6126
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 85-355 of human SCNN1G (NP_001030.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:SH-SY5Y, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 85-355 of human SCNN1G (NP_001030.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IKVH FRKL DFPA VTIC NINP YKYS TVRH LLAD LEQE TREA LKSL YGFP ESRK RREA ESWN SVSE GKQP RFSH RIPL LIFD QDEK GKAR DFFT GRKR KVGG SIIH KASN VMHI ESKQ VVGF QLCS NDTS DCAT YTFS SGIN AIQE WYKL HYMN IMAQ VPLE KKIN MSYS AEEL LVTC FFDG VSCD ARNF TLFH HPMH GNCY TFNN RENE TILS TSMG GSEY GLQV ILYI NEEE YNPF LVSS TGAK VIIH RQDE YPFV EDVG TEIE TAMV TSI
Gene ID:6340
Uniprot:P51170
Cellular Location:Apical cell membrane, Multi-pass membrane protein
Calculated MW:74kDa
Observed MW:80kDa
Synonyms:SCNN1G, BESC3, ENaCg, ENaCgamma, PHA1, SCNEG
Background:Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome.
UniProt Protein Function:ENaC-gamma: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1G are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Channel, sodium

Chromosomal Location of Human Ortholog: 16p12

Cellular Component: apical plasma membrane; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function:amiloride-sensitive sodium channel activity; ion channel activity; protein binding; sodium channel activity; WW domain binding

Biological Process: excretion; multicellular organismal water homeostasis; response to stimulus; sensory perception of taste; sodium ion homeostasis; sodium ion transport; transmembrane transport

Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 3; Liddle Syndrome; Pseudohypoaldosteronism, Type I, Autosomal Recessive

NCBI Summary:Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
UniProt Code:P51170
NCBI GenInfo Identifier:108885072
NCBI Gene ID:6340
NCBI Accession:P51170.4
UniProt Secondary Accession:P51170,P78437, Q6PCC2, Q93023, Q93024, Q93025, Q93026 Q93027, Q96TD2,
UniProt Related Accession:P51170
Molecular Weight:74,270 Da
NCBI Full Name:Amiloride-sensitive sodium channel subunit gamma
NCBI Synonym Full Names:sodium channel epithelial 1 gamma subunit
NCBI Official Symbol:SCNN1G  
NCBI Official Synonym Symbols:PHA1; BESC3; ENaCg; SCNEG; ENaCgamma  
NCBI Protein Information:amiloride-sensitive sodium channel subunit gamma
UniProt Protein Name:Amiloride-sensitive sodium channel subunit gamma
UniProt Synonym Protein Names:Epithelial Na(+) channel subunit gamma; ENaCG; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG
Protein Family:Amiloride-sensitive sodium channel
UniProt Gene Name:SCNN1G  
UniProt Entry Name:SCNNG_HUMAN
Anti-SCNN1G Antibody (CAB6126)Western blot analysis of extracts of various cell lines, using SCNN1G antibody (CAB6126) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.
Anti-SCNN1G Antibody (CAB6126)Immunohistochemistry of paraffin-embedded mouse lung using SCNN1G antibody (CAB6126) at dilution of 1:100 (40x lens).
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