Signal Transduction Antibodies 1

Anti-SCNN1D Antibody (CAB10242)

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SKU:
CAB10242
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SCNN1D Antibody
Antibody SKU:CAB10242
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 540-680 of human SCNN1D (NP_001123885.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A-549, MCF7, Mouse brain, Mouse liver, Rat brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 540-680 of human SCNN1D (NP_001123885.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GVEV ELLH NTSY TRQA CLVS CFQQ LMVE TCSC GYYL HPLP AGAE YCSS ARHP AWGH CFYR LYQD LETH RLPC TSRC PRPC RESA FKLS TGTS RWPS AKSA GWTL ATLG EQGL PHQS HRQR SSLA KINI VYQE LNYR SVEE A
Gene ID:6339
Uniprot:P51172
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:70kDa/77kDa
Observed MW:70kDa
Synonyms:SCNN1D, ENaCd, ENaCdelta, SCNED, dNaCh
Background:
UniProt Protein Function:ENaC-delta: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: actin cytoskeleton; membrane; plasma membrane

Molecular Function:protein binding

Biological Process: sodium ion transport

UniProt Code:P51172
NCBI GenInfo Identifier:116242784
NCBI Gene ID:6339
NCBI Accession:P51172.2
UniProt Secondary Accession:P51172,Q08AQ3, Q09HT0, Q5T7L3, Q8NA24, A9Z1X6, B1PS44
UniProt Related Accession:P51172
Molecular Weight:70kDa
NCBI Full Name:Amiloride-sensitive sodium channel subunit delta
NCBI Synonym Full Names:sodium channel epithelial 1 delta subunit
NCBI Official Symbol:SCNN1D  
NCBI Official Synonym Symbols:ENaCd; SCNED; dNaCh; ENaCdelta  
NCBI Protein Information:amiloride-sensitive sodium channel subunit delta
UniProt Protein Name:Amiloride-sensitive sodium channel subunit delta
UniProt Synonym Protein Names:Delta-NaCH; Epithelial Na(+) channel subunit delta; Delta-ENaC; ENaCD; Nonvoltage-gated sodium channel 1 subunit delta; SCNED
Protein Family:Amiloride-sensitive sodium channel
UniProt Gene Name:SCNN1D  
Anti-SCNN1D Antibody (CAB10242)Western blot analysis of extracts of various cell lines, using SCNN1D antibody (CAB10242) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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