Name: Anti-SCN7A Antibody (CAB10088)
Brand: Signal Transduction Antibodies 1
SKU: CAB10088
Availability: OutOfStock

Antibody Name:	Anti-SCN7A Antibody
Antibody SKU:	CAB10088
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 265-368 of human SCN7A (NP_002967.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	HeLa, HT-1080, Mouse heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 265-368 of human SCN7A (NP_002967.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	HKCF RWPQ ENEN ETLH NRTG NPYY IRET ENFY YLEG ERYA LLCG NRTD AGQC PEGY VCVK AGIN PDQG FTNF DSFG WALF ALFR LMAQ DYPE VLYH QILY ASGK
Gene ID:	6332
Uniprot:	Q01118
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	193kDa
Observed MW:	260kDa

Synonyms:

SCN7A, NaG, Nav2.1, Nav2.2, SCN6A

Background:

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.

UniProt Protein Function:	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
NCBI Summary:	This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]
UniProt Code:	Q01118
NCBI GenInfo Identifier:	111378393
NCBI Gene ID:	6332
NCBI Accession:	NP_002967.2
UniProt Related Accession:	Q01118
Molecular Weight:	193,493 Da
NCBI Full Name:	sodium channel protein type 7 subunit alpha
NCBI Synonym Full Names:	sodium voltage-gated channel alpha subunit 7
NCBI Official Symbol:	SCN7A
NCBI Official Synonym Symbols:	NaG; SCN6A; Nav2.1; Nav2.2
NCBI Protein Information:	sodium channel protein type 7 subunit alpha
UniProt Protein Name:	Sodium channel protein type 7 subunit alpha
UniProt Synonym Protein Names:	Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type VII subunit alpha
Protein Family:	Sodium channel protein
UniProt Gene Name:	SCN7A

Western blot analysis of extracts of various cell lines, using SCN7A antibody (CAB10088) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

SCN7A Antibody (PACO04989)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)