Signal Transduction Antibodies 1
Anti-SCN7A Antibody (CAB10088)
- SKU:
- CAB10088
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-SCN7A Antibody |
Antibody SKU: | CAB10088 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-368 of human SCN7A (NP_002967.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse |
Positive Samples: | HeLa, HT-1080, Mouse heart |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-368 of human SCN7A (NP_002967.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | HKCF RWPQ ENEN ETLH NRTG NPYY IRET ENFY YLEG ERYA LLCG NRTD AGQC PEGY VCVK AGIN PDQG FTNF DSFG WALF ALFR LMAQ DYPE VLYH QILY ASGK |
Gene ID: | 6332 |
Uniprot: | Q01118 |
Cellular Location: | Membrane, Multi-pass membrane protein |
Calculated MW: | 193kDa |
Observed MW: | 260kDa |
Synonyms: | SCN7A, NaG, Nav2.1, Nav2.2, SCN6A |
Background: | This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. |
UniProt Protein Function: | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. |
NCBI Summary: | This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q01118 |
NCBI GenInfo Identifier: | 111378393 |
NCBI Gene ID: | 6332 |
NCBI Accession: | NP_002967.2 |
UniProt Related Accession: | Q01118 |
Molecular Weight: | 193,493 Da |
NCBI Full Name: | sodium channel protein type 7 subunit alpha |
NCBI Synonym Full Names: | sodium voltage-gated channel alpha subunit 7 |
NCBI Official Symbol: | SCN7A |
NCBI Official Synonym Symbols: | NaG; SCN6A; Nav2.1; Nav2.2 |
NCBI Protein Information: | sodium channel protein type 7 subunit alpha |
UniProt Protein Name: | Sodium channel protein type 7 subunit alpha |
UniProt Synonym Protein Names: | Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type VII subunit alpha |
Protein Family: | Sodium channel protein |
UniProt Gene Name: | SCN7A |
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