Signal Transduction Antibodies 2
Anti-SCN5A Antibody (CAB16665)
- SKU:
- CAB16665
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SCN5A Antibody |
| Antibody SKU: | CAB16665 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of mouse SCN5A |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung |
| Immunogen: | A synthetic peptide of mouse SCN5A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6331 |
| Uniprot: | Q14524 |
| Cellular Location: | |
| Calculated MW: | 221kDa/223kDa/224kDa/226kDa |
| Observed MW: | 226kDa |
| Synonyms: | SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1 |
| Background: | The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. |
| UniProt Protein Function: | SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, sodium; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21 Cellular Component: caveola; cell surface; endoplasmic reticulum; integral to membrane; intracellular; lateral plasma membrane; plasma membrane; sarcolemma; T-tubule; voltage-gated sodium channel complex; Z disc Molecular Function:ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity Biological Process: cardiac muscle contraction; cerebellum development; generation of action potential; membrane depolarization; odontogenesis of dentine-containing teeth; positive regulation of action potential; positive regulation of epithelial cell proliferation; regulation of heart rate; response to denervation involved in regulation of muscle adaptation; sodium ion transport; telencephalon development Disease: Atrial Fibrillation, Familial, 10; Brugada Syndrome 1; Cardiomyopathy, Dilated, 1e; Long Qt Syndrome 3; Progressive Familial Heart Block, Type Ia; Sick Sinus Syndrome 1, Autosomal Recessive; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14524 |
| NCBI GenInfo Identifier: | 215273881 |
| NCBI Gene ID: | 6331 |
| NCBI Accession: | Q14524.2 |
| UniProt Secondary Accession: | Q14524,Q59H93, Q75RX9, Q75RY0, A5H1P8, A6N922, A6N923 B2RTU0, E7ET19, E9PEF3, E9PEK2, E9PFW7, |
| UniProt Related Accession: | Q14524 |
| Molecular Weight: | 224,917 Da |
| NCBI Full Name: | Sodium channel protein type 5 subunit alpha |
| NCBI Synonym Full Names: | sodium voltage-gated channel alpha subunit 5 |
| NCBI Official Symbol: | SCN5A |
| NCBI Official Synonym Symbols: | HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5 |
| NCBI Protein Information: | sodium channel protein type 5 subunit alpha |
| UniProt Protein Name: | Sodium channel protein type 5 subunit alpha |
| UniProt Synonym Protein Names: | HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5 |
| Protein Family: | Sodium channel protein |
| UniProt Gene Name: | SCN5A |
| UniProt Entry Name: | SCN5A_HUMAN |
 | Western blot analysis of extracts of mouse lung, using SCN5A antibody (CAB16665) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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