Signal Transduction Antibodies 1

Anti-SCN3A Antibody (CAB10072)

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SKU:
CAB10072
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SCN3A Antibody
Antibody SKU:CAB10072
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 274-400 of human SCN3A (NP_008853.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:293T, HT-1080
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 274-400 of human SCN3A (NP_008853.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RNKC LQWP PSDS AFET NTTS YFNG TMDS NGTF VNVT MSTF NWKD YIGD DSHF YVLD GQKD PLLC GNGS DAGQ CPEG YICV KAGR NPNY GYTS FDTF SWAF LSLF RLMT QDYW ENLY QLTL RAAG KTY
Gene ID:6328
Uniprot:Q9NY46
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:221kDa/226kDa
Observed MW:350kDa
Synonyms:SCN3A, NAC3, Nav1.3
Background:Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SCN3A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q24

Cellular Component: voltage-gated sodium channel complex; cytoplasm; plasma membrane

Molecular Function:voltage-gated sodium channel activity

Biological Process: sodium ion transport; generation of action potential

NCBI Summary:Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NY46
NCBI GenInfo Identifier:126362955
NCBI Gene ID:6328
NCBI Accession:NP_001075146.1
UniProt Secondary Accession:Q9NY46,Q16142, Q53SX0, Q9BZB3, Q9C006, Q9NYK2, Q9P2J1 Q9UPD1, Q9Y6P4,
UniProt Related Accession:Q9NY46
Molecular Weight:226,294 Da
NCBI Full Name:sodium channel protein type 3 subunit alpha isoform 3
NCBI Synonym Full Names:sodium channel, voltage-gated, type III, alpha subunit
NCBI Official Symbol:SCN3A  
NCBI Official Synonym Symbols:NAC3; Nav1.3  
NCBI Protein Information:sodium channel protein type 3 subunit alpha; brain III voltage-gated sodium channel; voltage-gated sodium channel subtype III; sodium channel protein type III subunit alpha; sodium channel protein brain III subunit alpha; voltage-gated sodium channel subunit alpha Nav1.3; sodium channel, voltage-gated, type III, alpha polypeptide
UniProt Protein Name:Sodium channel protein type 3 subunit alpha
UniProt Synonym Protein Names:Sodium channel protein brain III subunit alpha; Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3
Protein Family:Sodium channel protein
UniProt Gene Name:SCN3A  
UniProt Entry Name:SCN3A_HUMAN
Anti-SCN3A Antibody (CAB10072)Western blot analysis of extracts of various cell lines, using SCN3A antibody (CAB10072) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.
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