Cell Biology Antibodies 15
Anti-SCIN Antibody (CAB17800)
(No reviews yet)
Write a Review
- SKU:
- CAB17800
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SCIN Antibody |
| Antibody SKU: | CAB17800 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of Human SCIN. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, SGC-7901 |
| Immunogen: | A synthetic peptide of Human SCIN. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 85477 |
| Uniprot: | Q9Y6U3 |
| Cellular Location: | |
| Calculated MW: | 52kDa/65kDa/80kDa |
| Observed MW: | 80kDa |
 | Western blot - SCIN Polyclonal Antibody (CAB17800) |
| Synonyms: | SCIN, adseverin |
| Background: | SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010] |
| UniProt Protein Function: | SCIN: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes. Belongs to the villin/gelsolin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p21.3 Cellular Component: protein complex; cytoskeleton; cytoplasm; cell cortex Molecular Function:actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; calcium ion binding; actin binding; phosphatidylinositol binding Biological Process: negative regulation of cell proliferation; actin filament severing; positive regulation of apoptosis; actin filament capping; positive regulation of secretion; positive regulation of megakaryocyte differentiation; regulation of chondrocyte differentiation; actin nucleation; calcium ion-dependent exocytosis |
| NCBI Summary: | SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010] |
| UniProt Code: | Q9Y6U3 |
| NCBI GenInfo Identifier: | 57015325 |
| NCBI Gene ID: | 85477 |
| NCBI Accession: | Q9Y6U3.4 |
| UniProt Secondary Accession: | Q9Y6U3,Q8NBZ6, Q8WU97, Q96JC7, Q96PY2, A8K2U8, |
| UniProt Related Accession: | Q9Y6U3 |
| Molecular Weight: | 715 |
| NCBI Full Name: | Adseverin |
| NCBI Synonym Full Names: | scinderin |
| NCBI Official Symbol: | SCIN |
| NCBI Protein Information: | adseverin |
| UniProt Protein Name: | Adseverin |
| UniProt Synonym Protein Names: | Scinderin |
| Protein Family: | Adseverin |
| UniProt Gene Name: | SCIN |
| UniProt Entry Name: | ADSV_HUMAN |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक