Neuroscience
Anti-SCGN Antibody (CAB12897)
- SKU:
- CAB12897
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SCGN Antibody |
| Antibody SKU: | CAB12897 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human SCGN (NP_008929.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye, Mouse brain, Rat pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human SCGN (NP_008929.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDSS REPT LGRL DAAG FWQV WQRF DADE KGYI EEKE LDAF FLHM LMKL GTDD TVMK ANLH KVKQ QFMT TQDA SKDG RIRM KELA GMFL SEDE NFLL LFRR ENPL DSSV EFMQ IWRK YDAD SSGF ISAA ELRN FLRD LFLH HKKA ISEA KLEE YTGT MMKI FDRN KDGR LDLN DLAR ILAL QENF LLQF KMDA CSTE ERKR DFEK IFAY YDVS KTGA LEGP EVDG FVKD MMEL VQPS ISGV DLDK FREI LLRH CDVN KDGK IQKS ELAL CLGL KINP |
| Gene ID: | 10590 |
| Uniprot: | O76038 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Peripheral membrane protein, Secreted, secretory vesicle membrane |
| Calculated MW: | 32kDa |
| Observed MW: | 27kDa |
| Synonyms: | SCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin |
| Background: | The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. |
| UniProt Protein Function: | SCGN: |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6p22.3-p22.1 Cellular Component: cytosol; neuron projection; nucleus; synapse Molecular Function:calcium ion binding Biological Process: cytosolic calcium ion homeostasis |
| NCBI Summary: | The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76038 |
| NCBI GenInfo Identifier: | 21264511 |
| NCBI Gene ID: | 10590 |
| NCBI Accession: | O76038.2 |
| UniProt Secondary Accession: | O76038,Q5VV44, Q96QV7, Q9UJF6, A8K0B2, |
| UniProt Related Accession: | O76038 |
| Molecular Weight: | 32,040 Da |
| NCBI Full Name: | Secretagogin |
| NCBI Synonym Full Names: | secretagogin, EF-hand calcium binding protein |
| NCBI Official Symbol: | SCGN |
| NCBI Official Synonym Symbols: | SEGN; CALBL; SECRET; setagin; DJ501N12.8 |
| NCBI Protein Information: | secretagogin |
| UniProt Protein Name: | Secretagogin |
| Protein Family: | Secretagogin |
| UniProt Gene Name: | SCGN |
| UniProt Entry Name: | SEGN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SCGN antibody (CAB12897) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Human breast cancer using SCGN Rabbit pAb (CAB12897) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat pancreas using SCGN Rabbit pAb (CAB12897) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using SCGN antibody (CAB12897) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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