Metabolism Antibodies 1

Anti-SCD5 Antibody (CAB13127)

(No reviews yet) Write a Review
SKU:
CAB13127
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SCD5 Antibody
Antibody SKU:CAB13127
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human SCD5 (NP_001032671.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human SCD5 (NP_001032671.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPGP ATDA GKIP FCDA KEEI RAGL ESSE GGGG PERP GARG QRQN IVWR NVVL MSLL HLGA VYSL VLIP KAKP LTL
Gene ID:79966
Uniprot:Q86SK9
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:28kDa/37kDa
Observed MW:38kDa
Synonyms:SCD5, ACOD4, FADS4, HSCD5, SCD2, SCD4
Background:
UniProt Protein Function:SCD5: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position. Belongs to the fatty acid desaturase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, multi-pass; Membrane protein, integral; EC 1.14.19.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q21.22

Cellular Component: endoplasmic reticulum membrane

Molecular Function:oxidoreductase activity; stearoyl-CoA 9-desaturase activity

Biological Process: unsaturated fatty acid biosynthetic process

NCBI Summary:Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
UniProt Code:Q86SK9
NCBI GenInfo Identifier:162416247
NCBI Gene ID:79966
NCBI Accession:Q86SK9.2
UniProt Secondary Accession:Q86SK9,Q4W5Q5, Q8NDS0, Q9H7D1, B2RPG0,
UniProt Related Accession:Q86SK9
Molecular Weight:28,983 Da
NCBI Full Name:Stearoyl-CoA desaturase 5
NCBI Synonym Full Names:stearoyl-CoA desaturase 5
NCBI Official Symbol:SCD5  
NCBI Official Synonym Symbols:SCD2; SCD4; ACOD4; FADS4; HSCD5  
NCBI Protein Information:stearoyl-CoA desaturase 5
UniProt Protein Name:Stearoyl-CoA desaturase 5
UniProt Synonym Protein Names:Acyl-CoA-desaturase 4; HSCD5
Protein Family:Stearoyl-CoA desaturase
UniProt Gene Name:SCD5  
UniProt Entry Name:SCD5_HUMAN
Anti-SCD5 Antibody (CAB13127)Western blot analysis of extracts of various cell lines, using SCD5 antibody (CAB13127) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products