Immunology Antibodies 2
Anti-SCARB1 Antibody (CAB1584)
- SKU:
- CAB1584
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-SCARB1 Antibody |
| Antibody SKU: | CAB1584 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCARB1 (NP_005496.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat ovary |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCARB1 (NP_005496.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGCS AKAR WAAG ALGV AGLL CAVL GAVM IVMV PSLI KQQV LKNV RIDP SSLS FNMW KEIP IPFY LSVY FFDV MNPS EILK GEKP QVRE RGPY VYRE FRHK |
| Gene ID: | 949 |
| Uniprot: | Q8WTV0 |
| Cellular Location: | Cell membrane, Membrane, Multi-pass membrane protein, caveola |
| Calculated MW: | 45kDa/53kDa/56kDa/60kDa |
| Observed MW: | 80kDa |
| Synonyms: | SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 |
| Background: | The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SCARB1: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Belongs to the CD36 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cell surface; lysosomal membrane; microvillus membrane; integral to plasma membrane; plasma membrane; caveola Molecular Function:apolipoprotein A-I binding; protein binding; protein homodimerization activity; lipopolysaccharide binding; transporter activity; phosphatidylserine binding; low-density lipoprotein binding; lipopolysaccharide receptor activity; apolipoprotein binding; high-density lipoprotein binding; phosphatidylinositol binding Biological Process: receptor-mediated endocytosis; wound healing; blood vessel endothelial cell migration; viral reproduction; positive regulation of nitric-oxide synthase activity; lipoprotein metabolic process; cholesterol efflux; androgen biosynthetic process; regulation of phagocytosis; recognition of apoptotic cell; lipopolysaccharide transport; cholesterol homeostasis; reverse cholesterol transport; detection of lipopolysaccharide; endothelial cell proliferation; lipopolysaccharide-mediated signaling pathway; adhesion to host; phospholipid transport; cholesterol catabolic process; cell adhesion Disease: High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 |
| NCBI Summary: | The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019] |
| UniProt Code: | Q8WTV0 |
| NCBI GenInfo Identifier: | 37999904 |
| NCBI Gene ID: | 949 |
| NCBI Accession: | Q8WTV0.1 |
| UniProt Related Accession: | Q8WTV0 |
| Molecular Weight: | ~ 80kDa |
| NCBI Full Name: | Scavenger receptor class B member 1 |
| NCBI Synonym Full Names: | scavenger receptor class B member 1 |
| NCBI Official Symbol: | SCARB1 |
| NCBI Official Synonym Symbols: | CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6 |
| NCBI Protein Information: | scavenger receptor class B member 1 |
| UniProt Protein Name: | Scavenger receptor class B member 1 |
| UniProt Synonym Protein Names: | CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD_antigen: CD36 |
| Protein Family: | Scavenger receptor |
| UniProt Gene Name: | SCARB1 |
| UniProt Entry Name: | SCRB1_HUMAN |
 | Western blot analysis of extracts of rat ovary, using SCARB1 Antibody (CAB1584) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
Related Products
