Anti-SATB2 Antibody (CAB20220)

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SKU:
CAB20220
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SATB2
Synonyms:
GLSS

Description

Product Name:SATB2 Rabbit mAb
Product Code:CAB20220
Size:50uL, 100uL
Synonyms:SATB2, GLSS
Applications:WB, IHC, IF, FC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SATB2.
Applications:WB, IHC, IF, FC
Recommended Dilutions:WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 FC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HCT116, NIH/3T3, Mouse brain, Rat brain
Immunogen:Recombinant protein of human SATB2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: TBS with 0.05% sodium azide, 0.05% BSA, 40% glycerol, pH7.4.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23314
Uniprot:Q9UPW6
Calculated MW:69kDa/82kDa
Observed MW:100KDa
UniProt Protein Function:SATB2: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI). A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis. A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22). Belongs to the CUT homeobox family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: nucleoplasm; transcription factor complex; nuclear matrix; cytoplasm; histone deacetylase complex

Molecular Function:protein binding; sequence-specific DNA binding; chromatin binding

Biological Process: chromatin remodeling; transcription, DNA-dependent; commitment of a neuronal cell to a specific type of neuron in the forebrain; cartilage development; neuron migration; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; palate development; embryonic pattern specification; osteoblast development; embryonic skeletal morphogenesis

Disease: Glass Syndrome

UniProt Code:Q9UPW6
NCBI GenInfo Identifier:13634020
NCBI Gene ID:
NCBI Accession:Q9UPW6.2
Molecular Weight:81kDa
NCBI Full Name:DNA-binding protein SATB2
UniProt Protein Name:DNA-binding protein SATB2
UniProt Synonym Protein Names:Special AT-rich sequence-binding protein 2
Protein Family:DNA-binding protein
UniProt Gene Name:SATB2  
UniProt Entry Name:SATB2_HUMAN
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