Epigenetics & Nuclear Signaling Antibodies 3

Anti-SAP30 Antibody (CAB17032)

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SKU:
CAB17032
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SAP30 Antibody
Antibody SKU:CAB17032
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human SAP30 (NP_003855.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human SAP30 (NP_003855.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IELD KSAR HLYI CDYH KNLI QSVR NRRK RKGS DDDG GDSP VQDI DTPE VDLY QLQV NTLR RYKR HFKL PTRP GLNK AQLV EIVG CHFR SIPV NEKD TLTY FIYS VKND KNKS DLKV DSGV H
Gene ID:8819
Uniprot:O75446
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:SAP30
Background:Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.
UniProt Protein Function:SAP30: Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. Belongs to the SAP30 family.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 4q34.1

Cellular Component: histone deacetylase complex; nucleoplasm

Molecular Function:histone deacetylase activity; protein binding; transcription corepressor activity

Biological Process: regulation of transcription, DNA-dependent

NCBI Summary:Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
UniProt Code:O75446
NCBI GenInfo Identifier:68053249
NCBI Gene ID:8819
NCBI Accession:O75446.1
UniProt Secondary Accession:O75446,D3DP38,
UniProt Related Accession:O75446
Molecular Weight:23,306 Da
NCBI Full Name:Histone deacetylase complex subunit SAP30
NCBI Synonym Full Names:Sin3A associated protein 30
NCBI Official Symbol:SAP30  
NCBI Protein Information:histone deacetylase complex subunit SAP30
UniProt Protein Name:Histone deacetylase complex subunit SAP30
UniProt Synonym Protein Names:30 kDa Sin3-associated polypeptide; Sin3 corepressor complex subunit SAP30; Sin3-associated polypeptide p30
Protein Family:SAP30-binding protein
UniProt Gene Name:SAP30  
UniProt Entry Name:SAP30_HUMAN
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