Epigenetics & Nuclear Signaling Antibodies 3

Anti-SAP18 Antibody (CAB4397)

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SKU:
CAB4397
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SAP18
Synonyms:
2HOR0202
Synonyms:
SAP18P
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:SAP18 Rabbit pAb
Product Code:CAB4397
Size:20uL, 50uL, 100uL
Synonyms:SAP18, 2HOR0202, SAP18P
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_005861.2).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_005861.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVES RVTQ EEIK KEPE KPID REKT CPLL LRVF TTNN GRHH RMDE FSRG NVPS SELQ IYTW MDAT LKEL TSLV KEVY PEAR KKGT HFNF AIVF TDVK RPGY RVKE IGST MSGR KGTD DSMT LQSQ KFQI GDYL DIAI TPPN RAPP PSGR MRPY
Gene ID:10284
Uniprot:O00422
Cellular Location:Cytoplasm, Nucleus, Nucleus speckle
Calculated MW:17kDa
Observed MW:18kDa
UniProt Protein Function:SAP18: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 13q12.11

Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nuclear speck

Molecular Function:protein binding; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; negative regulation of nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; positive regulation of apoptosis; RNA splicing; gene expression; mRNA processing; regulation of gene expression, epigenetic; regulation of alternative nuclear mRNA splicing, via spliceosome

NCBI Summary:Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
UniProt Code:O00422
NCBI GenInfo Identifier:6831678
NCBI Gene ID:10284
NCBI Accession:O00422.1
UniProt Related Accession:O00422
Molecular Weight:
NCBI Full Name:Histone deacetylase complex subunit SAP18
NCBI Synonym Full Names:Sin3A associated protein 18
NCBI Official Symbol:SAP18  
NCBI Official Synonym Symbols:SAP18P; 2HOR0202  
NCBI Protein Information:histone deacetylase complex subunit SAP18
UniProt Protein Name:Histone deacetylase complex subunit SAP18
UniProt Synonym Protein Names:18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18
Protein Family:Zinc finger A20 domain-containing stress-associated protein
UniProt Gene Name:SAP18  
UniProt Entry Name:SAP18_HUMAN
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