Cell Cycle Antibodies 2

Anti-SAM68 Antibody (CAB3886)

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SKU:
CAB3886
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-SAM68 Antibody
Antibody SKU:CAB3886
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SAM68
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, NIH/3T3, Jurkat, Rat testis
Immunogen:A synthesized peptide derived from human SAM68
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10657
Uniprot:Q07666
Cellular Location:
Calculated MW:68 kDa
Observed MW:68KDa
Synonyms:Sam68, p62, p68
Background:This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Protein Function:KHDRBS1: a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear ribonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus

Molecular Function:identical protein binding; protein binding; SH3/SH2 adaptor activity; DNA binding; RNA binding; protein complex binding; poly(U) binding; SH3 domain binding; poly(A) binding

Biological Process: transcription, DNA-dependent; positive regulation of signal transduction; positive regulation of RNA export from nucleus; regulation of protein stability; signal transduction; positive regulation of translational initiation; cell proliferation; cell surface receptor linked signal transduction; regulation of RNA export from nucleus; mRNA processing; cell cycle arrest; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Code:Q07666
NCBI GenInfo Identifier:62511098
NCBI Gene ID:10657
NCBI Accession:Q07666.1
UniProt Related Accession:Q07666
Molecular Weight:~ 48kDa
NCBI Full Name:KH domain-containing, RNA-binding, signal transduction-associated protein 1
NCBI Synonym Full Names:KH RNA binding domain containing, signal transduction associated 1
NCBI Official Symbol:KHDRBS1  
NCBI Official Synonym Symbols:p62; p68; Sam68  
NCBI Protein Information:KH domain-containing, RNA-binding, signal transduction-associated protein 1
UniProt Protein Name:KH domain-containing, RNA-binding, signal transduction-associated protein 1
UniProt Synonym Protein Names:GAP-associated tyrosine phosphoprotein p62; Src-associated in mitosis 68 kDa protein; Sam68; p21 Ras GTPase-activating protein-associated p62; p68
UniProt Gene Name:KHDRBS1  
UniProt Entry Name:KHDR1_HUMAN
Anti-SAM68 Antibody (CAB3886)Western blot - SAM68 Rabbit mAb (CAB3886)
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