Epigenetics & Nuclear Signaling Antibodies 3

Anti-SAFB2 Antibody (CAB4330)

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SKU:
CAB4330
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SAFB2 Antibody
Antibody SKU:CAB4330
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human SAFB2 (NP_055464.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Jurkat, Mouse liver, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human SAFB2 (NP_055464.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAET LPGS GDSG PGTA SLGP GVAE TGTR RLSE LRVI DLRA ELKK RNLD TGGN KSVL MERL KKAV KEEG QDPD EIGI ELEA TSKK SAKR CVKG LKME EEGT EDNG LEDD SRDG QEDM EASL ENLQ NMGM MDMS VLDE TEVA NSSA PDFG EDGT DGLL DSFC DSKE YVAA QLRQ LPAQ PPEH AVDG EGFK NTLE TSSL NFKV TPDI EESL LEPE NEKI LDIL GETC KSEP VKEE SSEL EQPF AQDT SSVG PDRK LAE
Gene ID:9667
Uniprot:Q14151
Cellular Location:Cytoplasm, Nucleus
Calculated MW:12kDa/107kDa
Observed MW:160kDa
Synonyms:SAFB2
Background:The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes.
UniProt Protein Function:SAFB2: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; RNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm

Molecular Function:identical protein binding; protein binding; DNA binding; nucleotide binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent

UniProt Code:Q14151
NCBI GenInfo Identifier:38372432
NCBI Gene ID:9667
NCBI Accession:Q14151.1
UniProt Secondary Accession:Q14151,Q8TB13, B4DKG3,
UniProt Related Accession:Q14151
Molecular Weight:953
NCBI Full Name:Scaffold attachment factor B2
NCBI Synonym Full Names:scaffold attachment factor B2
NCBI Official Symbol:SAFB2  
NCBI Protein Information:scaffold attachment factor B2; SAF-B2
UniProt Protein Name:Scaffold attachment factor B2
Protein Family:Scaffold attachment factor
UniProt Gene Name:SAFB2  
UniProt Entry Name:SAFB2_HUMAN
Anti-SAFB2 Antibody (CAB4330)Western blot analysis of extracts of various cell lines, using SAFB2 antibody (CAB4330) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-SAFB2 Antibody (CAB4330)Immunohistochemistry of paraffin-embedded human prostate using SAFB2 antibody (CAB4330) at dilution of 1:100 (40x lens).
Anti-SAFB2 Antibody (CAB4330)Immunohistochemistry of paraffin-embedded rat brain using SAFB2 antibody (CAB4330) at dilution of 1:100 (40x lens).
Anti-SAFB2 Antibody (CAB4330)Immunohistochemistry of paraffin-embedded mouse brain using SAFB2 antibody (CAB4330) at dilution of 1:100 (40x lens).
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