Anti-SAE1 Antibody (CAB0891)
- SKU:
- CAB0891
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AOS1
- Synonyms:
- HSPC140
- Synonyms:
- SUA1
- Synonyms:
- UBLE1A
Description
| Product Name: | SAE1 Rabbit mAb |
| Product Code: | CAB0891 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AOS1, HSPC140, SUA1, UBLE1A |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SAE1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, MCF7, DU145, Mouse testis, Mouse thymus, Rat testis |
| Immunogen: | A synthesized peptide derived from human SAE1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10055 |
| Uniprot: | Q9UBE0 |
| Calculated MW: | 38kDa |
| Observed MW: | 40kDa |
| UniProt Protein Function: | UBLE1A: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:ATP-dependent protein binding; enzyme activator activity; protein binding; protein C-terminus binding; protein heterodimerization activity; SUMO activating enzyme activity; ubiquitin activating enzyme activity Biological Process: protein sumoylation; protein ubiquitination; regulation of mitotic cell cycle |
| NCBI Summary: | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
| UniProt Code: | Q9UBE0 |
| NCBI GenInfo Identifier: | 42559897 |
| NCBI Gene ID: | 10055 |
| NCBI Accession: | Q9UBE0.1 |
| UniProt Secondary Accession: | Q9UBE0,O95717, Q9P020, B2RDP5, B3KMQ2, F5GXX7, G3XAK6 |
| UniProt Related Accession: | Q9UBE0 |
| Molecular Weight: | 33,063 Da |
| NCBI Full Name: | SUMO-activating enzyme subunit 1 |
| NCBI Synonym Full Names: | SUMO1 activating enzyme subunit 1 |
| NCBI Official Symbol: | SAE1 |
| NCBI Official Synonym Symbols: | AOS1; SUA1; UBLE1A; HSPC140 |
| NCBI Protein Information: | SUMO-activating enzyme subunit 1 |
| UniProt Protein Name: | SUMO-activating enzyme subunit 1 |
| UniProt Synonym Protein Names: | Ubiquitin-like 1-activating enzyme E1A |
| Protein Family: | SUMO-activating enzyme |
| UniProt Gene Name: | SAE1 |
| UniProt Entry Name: | SAE1_HUMAN |
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