Anti-S6 Ribosomal Protein (RPS6) Antibody (CAB11874)

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SKU:
CAB11874
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
S6
Research Area:
Cell Biology

Description

Product Name:S6 Ribosomal Protein (RPS6) Rabbit mAb
Product Code:CAB11874
Size:50uL
Synonyms:RPS6, S6, RPS6
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RPS6
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, Mouse thymus, Mouse liver, Rat liver
Immunogen:Recombinant protein of human RPS6
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6194
Uniprot:P62753
Calculated MW:28kDa
Observed MW:32kDa
UniProt Protein Function:S6: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the ribosomal protein S6e family.
UniProt Protein Details:

Protein type:Translation

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: polysome; small ribosomal subunit; membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex; cytosol

Molecular Function:protein binding; structural constituent of ribosome; protein kinase binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; erythrocyte development; TOR signaling pathway; viral reproduction; translation; positive regulation of apoptosis; T cell differentiation in the thymus; gastrulation; translational termination; viral infectious cycle; glucose homeostasis; oogenesis stage; T cell proliferation during immune response; translational initiation; ribosomal small subunit assembly and maintenance; viral transcription; activated T cell apoptosis; placenta development; mitosis; mitotic cell cycle checkpoint; ribosomal small subunit biogenesis and assembly; translational elongation; cellular protein metabolic process; insulin receptor signaling pathway; mRNA catabolic process, nonsense-mediated decay; gene expression; rRNA processing; G1/S transition of mitotic cell cycle; negative regulation of apoptosis

NCBI Summary:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
UniProt Code:P62753
NCBI GenInfo Identifier:51338632
NCBI Gene ID:6194
NCBI Accession:P62753.1
UniProt Secondary Accession:P62753,P08227, P10660, Q4VBY7, Q8N6Z7,
UniProt Related Accession:P62753
Molecular Weight:249
NCBI Full Name:40S ribosomal protein S6
NCBI Synonym Full Names:ribosomal protein S6
NCBI Official Symbol:RPS6  
NCBI Official Synonym Symbols:S6  
NCBI Protein Information:40S ribosomal protein S6; phosphoprotein NP33
UniProt Protein Name:40S ribosomal protein S6
UniProt Synonym Protein Names:Phosphoprotein NP33
Protein Family:30S ribosomal protein
UniProt Gene Name:RPS6  
UniProt Entry Name:RS6_HUMAN
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