Epigenetics & Nuclear Signaling Antibodies 3

Anti-RXRG Antibody (CAB1877)

(No reviews yet) Write a Review
SKU:
CAB1877
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-RXRG Antibody
Antibody SKU:CAB1877
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human RXRG (NP_008848.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, DU145, U-87MG, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human RXRG (NP_008848.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYGN YSHF MKFP AGYG GSPG HTGS TSMS PSAA LSTG KPMD SHPS YTDT PVSA PRTL SAVG TPLN ALGS PYRV ITSA MGPP SGAL AAPP GINL VAPP SSQL NVVN SVSS SEDI KPLP GLPG IGNM NYPS TSPG SLVK H
Gene ID:6258
Uniprot:P48443
Cellular Location:Nucleus
Calculated MW:50kDa
Observed MW:61kDa
Synonyms:RXRG, NR2B3, RXRC
Background:This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.
UniProt Protein Function:RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily.
UniProt Protein Details:

Protein type:DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nucleoplasm

Molecular Function:protein binding; zinc ion binding; retinoid-X receptor activity; steroid hormone receptor activity

Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; regulation of myelination; heart development; steroid hormone mediated signaling; gene expression; transmembrane transport; protein homotetramerization; peripheral nervous system development

NCBI Summary:This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
UniProt Code:P48443
NCBI GenInfo Identifier:1350913
NCBI Gene ID:6258
NCBI Accession:P48443.1
UniProt Secondary Accession:P48443,Q6IBU7, A6NIP1,
UniProt Related Accession:P48443
Molecular Weight:50,871 Da
NCBI Full Name:Retinoic acid receptor RXR-gamma
NCBI Synonym Full Names:retinoid X receptor, gamma
NCBI Official Symbol:RXRG  
NCBI Official Synonym Symbols:RXRC; NR2B3  
NCBI Protein Information:retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3
UniProt Protein Name:Retinoic acid receptor RXR-gamma
UniProt Synonym Protein Names:Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma
UniProt Gene Name:RXRG  
UniProt Entry Name:RXRG_HUMAN
Anti-RXRG Antibody (CAB1877)Western blot analysis of extracts of various cell lines, using RXRG antibody (CAB1877) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-RXRG Antibody (CAB1877)Immunohistochemistry of paraffin-embedded rat spleen using RXRG antibody (CAB1877) at dilution of 1:100 (40x lens).
Anti-RXRG Antibody (CAB1877)Immunohistochemistry of paraffin-embedded mouse testis using RXRG antibody (CAB1877) at dilution of 1:100 (40x lens).
Anti-RXRG Antibody (CAB1877)Immunohistochemistry of paraffin-embedded mouse brain using RXRG antibody (CAB1877) at dilution of 1:100 (40x lens).
View AllClose

0 Reviews

View AllClose

Related Products