Cell Biology Antibodies 4

Anti-RXFP2 Antibody (CAB14301)

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SKU:
CAB14301
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RXFP2 Antibody
Antibody SKU:CAB14301
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human RXFP2 (NP_570718.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human RXFP2 (NP_570718.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CGDT SGWA TIFG TVHG NANS VALT QECF LKQY PQCC DCKE TELE CVNG DLKS VPMI SNNV TLLS LKKN KIHS LPDK VFIK YTKL KKIF LQHN CIRH ISRK A
Gene ID:122042
Uniprot:Q8WXD0
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:83kDa/86kDa
Observed MW:86kDa
Synonyms:RXFP2, GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2
Background:This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:LGR8: the relaxin receptor is a G-protein coupled receptor (GPCR) that leads to the stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 13q13.1

Cellular Component: plasma membrane

Molecular Function:G-protein coupled receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger

Disease: Cryptorchidism, Unilateral Or Bilateral

NCBI Summary:This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Code:Q8WXD0
NCBI GenInfo Identifier:21362625
NCBI Gene ID:122042
NCBI Accession:Q8WXD0.1
UniProt Secondary Accession:Q8WXD0,Q3KU23, B1ALE9,
UniProt Related Accession:Q8WXD0
Molecular Weight:83,736 Da
NCBI Full Name:Relaxin receptor 2
NCBI Synonym Full Names:relaxin/insulin like family peptide receptor 2
NCBI Official Symbol:RXFP2  
NCBI Official Synonym Symbols:LGR8; GREAT; GPR106; INSL3R; LGR8.1; RXFPR2  
NCBI Protein Information:relaxin receptor 2
UniProt Protein Name:Relaxin receptor 2
UniProt Synonym Protein Names:G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2
Protein Family:Relaxin receptor
UniProt Gene Name:RXFP2  
UniProt Entry Name:RXFP2_HUMAN
Anti-RXFP2 Antibody (CAB14301)Western blot analysis of extracts of various cell lines, using RXFP2 antibody (CAB14301) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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